D26202
3,5-Diamino-1,2,4-triazole
98%
Synonym(s):
Guanazole
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About This Item
Empirical Formula (Hill Notation):
C2H5N5
CAS Number:
Molecular Weight:
99.09
Beilstein:
112467
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22
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Quality Level
Assay
98%
form
solid
mp
202-205 °C (lit.)
SMILES string
Nc1n[nH]c(N)n1
InChI
1S/C2H5N5/c3-1-5-2(4)7-6-1/h(H5,3,4,5,6,7)
InChI key
PKWIYNIDEDLDCJ-UHFFFAOYSA-N
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Application
Inhibitor of DNA synthesis.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Aquatic Chronic 2 - Repr. 2 - STOT RE 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
Certificates of Analysis (COA)
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W Suter et al.
Mutation research, 231(2), 251-264 (1990-08-01)
Guanazole and aphidicolin were chosen as candidates in the search for a selective, non-genotoxic inhibitor of DNA replication which could be used instead of hydroxyurea to measure DNA repair synthesis in rat hepatocyte primary cultures by liquid scintillation counting. The
L Guennoun et al.
Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy, 78(1), 347-353 (2010-11-30)
The 3,5-diamino-1,2,4-triazole (guanazole) was investigated by vibrational spectroscopy and quantum methods. The solid phase FT-IR and FT-Raman spectra were recorded in the region 4000-400 cm(-1) and 3600-50 cm(-1) respectively, and the band assignments were supported by deuteration effects. The results
A Sato et al.
Advances in enzyme regulation, 22, 231-241 (1984-01-01)
The data presented here show that while the non-heme iron subunit of ribonucleotide reductase is inhibited by IMPY, hydroxyurea and MAIQ, the mechanism of inhibition by hydroxyurea and IMPY is distinct from that for MAIQ. This difference in mechanisms is
V M Kolb et al.
Journal of molecular evolution, 38, 549-557 (1994-01-01)
Urazole is a five-membered heterocyclic compound which is isosteric with uracil's hydrogen-bonding segment. Urazole reacts spontaneoulsy with ribose (and other aldoses) to give a mixture of four ribosides: alpha and beta pyranosides and furanosides. This reaction occurs in aqueous solution
A A Alhaider et al.
Journal of pharmaceutical sciences, 71(1), 89-94 (1982-01-01)
A series of guanazole prodrugs, which are less water soluble than the parent compound and have relatively higher molecular weights, was recently synthesized, and their antineoplastic activities were measured in vitro. In present work, the ionization constants and partition coefficients
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