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765511

Sigma-Aldrich

Gold nanoparticles

20 nm diameter, carboxylic acid functionalized, PEG 5000 coated, OD 50, dispersion in H2O

Synonym(s):

Gold nanoparticles COOH functionalized, Au NP COOH, Gold Colloid

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About This Item

UNSPSC Code:
12162002
NACRES:
NA.23

material

PEG 5000

Quality Level

100

form

dispersion in H2O
nanoparticles

packaging

poly bottle of 1 mL

OD

50

diameter

20 nm

pH

6.0-8.0 (25 °C)

solubility

water: miscible

density

1.00 g/cm3

λmax

520 nm

functional group

carboxylic acid

storage temp.

2-8°C

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General description

Carboxylic acid functionalized GNPs form conjugates with various protein molecules due to the electrostatic attraction between negatively charged carboxylate groups and positively charged amino groups of protein.

Application

Carboxylic acid functionalized, PEG 5000 coated, OD 50, and H2O dispersed gold nanoparticles can be potentially used in the development of biosensors, cancer-cell imaging, drug delivery, and photothermal therapy.
AuNPs may be used to prepare SARS-CoV-2 conjugate for COVID-19 detection using lateral flow immunoassay technique. It may also be used in the immobilization of antibodies to improve the sensitivity of optical fiber sensors for the screening of COVID-19. It can also be deposited on the titanium electrode for the formation of a miniaturized device for the electrochemical detection of DNA hybridization.
The carboxylic acid group binds with various proteins and can be used in targeted drug delivery and gene therapy.
Functionalized Particles have been extensively used to study cellular uptake of nanoparticles and targeted drug delivery.

Features and Benefits

Decreases the cytotoxicity and increases efficiency of GNPs in targeted drug delivery. The PEG increases the stability of the nanoparticles and prevents agglomeration.

Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number
MKCQ4424
MKCW5552
MKBZ0088V
MKBL5794V

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Development and clinical application of a rapid IgM-IgG combined antibody test for SARS-CoV-2 infection diagnosis
Li Z, et al.
Journal of Medical Virology, 6, 2071-2071 (2020)
Size-dependent in vivo toxicity of PEG-coated gold nanoparticles
Zhang X, et al.
International journal of nanomedicine, 6, 2071-2071 (2011)
Nishima Wangoo et al.
Journal of colloid and interface science, 323(2), 247-254 (2008-05-20)
We report a novel strategy for the synthesis of aqueous stable, carboxylated gold nanoparticles (GNPs) by using glutamic acid as the reducing agent. The ratio of chloroaurate ions, AuCl(-)(4) to glutamic acid was optimized in the reaction medium to obtain
Optical Fiber Sensors for Rapid Screening of COVID-19
Nag P, et al.
Transactions of the Indian National Academy of Engineering, 143(9), 1-4 (2020)
Recent advances in nanoparticle-based lateral flow immunoassay as a point-of-care diagnostic tool for infectious agents and diseases
Banerjee R and Jaiswal A
Analyst, 143(9), 1970-1996 (2018)
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