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705551

Sigma-Aldrich

Hydrogen chloride solution

3 M in cyclopentyl methyl ether (CPME)

Synonym(s):

Hydrochloric acid in CPME

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About This Item

Empirical Formula (Hill Notation):
HCl
CAS Number:
Molecular Weight:
36.46
MDL number:
UNSPSC Code:
12352301
PubChem Substance ID:
NACRES:
NA.22

form

liquid

Quality Level

concentration

2.85-3.30 M (silver nitrate titration)
3 M in cyclopentyl methyl ether (CPME)

bp

106 °C

density

0.895 g/mL at 25 °C

storage temp.

2-8°C

SMILES string

Cl

InChI

1S/ClH/h1H

InChI key

VEXZGXHMUGYJMC-UHFFFAOYSA-N

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Application

Hydrogen chloride solution can be used in the Pinner synthesis of imidate hydrochlorides, which involves acid-catalyzed condensation of a nitrile and an alcohol under anhydrous conditions.

Signal Word

Danger

Hazard Classifications

Acute Tox. 4 Oral - Eye Irrit. 2 - Flam. Liq. 2 - Met. Corr. 1 - Skin Irrit. 2 - STOT SE 3

Target Organs

Respiratory system

Storage Class Code

3 - Flammable liquids

WGK

WGK 2

Flash Point(F)

50.0 °F

Flash Point(C)

10 °C

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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The Chemistry of Imidates.
Roger R and Neilson D G
Chemical Reviews, 61(2), 179-211 (1961)
Marta Kolodziejczak et al.
ACS chemical neuroscience, 6(7), 1219-1230 (2015-04-11)
Maturation of functional neuronal circuits during central nervous system development relies on sophisticated mechanisms. First, axonal and dendritic growth should reach appropriate targets for correct synapse elaboration. Second, pruning and neuronal death are required to eliminate redundant or inappropriate neuronal
Douglas M McMillan et al.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 40(7), 1804-1812 (2015-01-30)
CYP2D metabolically activates codeine to morphine, which is required for codeine analgesia. Permeability across the blood-brain barrier, and active efflux, suggests that initial morphine in the brain after codeine is due to brain CYP2D metabolism. Human CYP2D is higher in
Davide R Ceratti et al.
Advanced materials (Deerfield Beach, Fla.), 27(34), 4958-4962 (2015-07-23)
A new, simple bi-phasic dip-coating method is developed. This method is considered as a great improvement of the technique for research, development and production, since expensive, rare, harmful, or time-evolving solutions can now be easily deposited on large surfaces and
Jeroen Aerts et al.
Brain structure & function, 220(5), 2675-2689 (2014-06-25)
Matrix metalloproteinases (MMPs) are Zn(2+)-dependent endopeptidases considered to be essential for normal brain development and neuroplasticity by modulating extracellular matrix proteins, receptors, adhesion molecules, growth factors and cytoskeletal proteins. Specifically, MMP-3 has recently been implicated in synaptic plasticity, hippocampus-dependent learning

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