Skip to Content
Merck
All Photos(1)

Key Documents

View All Documentation

631175

Sigma-Aldrich

Methyl 6-chloropyridine-3-carboxylate

98%

Synonym(s):

Methyl 6-chloronicotinate, Methyl 6-chloro-3-picolinate

Sign Into View Organizational & Contract Pricing
All Photos(1)

About This Item

Empirical Formula (Hill Notation):
C7H6ClNO2
CAS Number:
73781-91-6
Molecular Weight:
171.58
MDL number:
MFCD00023420
UNSPSC Code:
12352100
PubChem Substance ID:
24882393
NACRES:
NA.22

Assay

98%

mp

86-90 °C (lit.)

functional group

chloro
ester

SMILES string

COC(=O)c1ccc(Cl)nc1

InChI

1S/C7H6ClNO2/c1-11-7(10)5-2-3-6(8)9-4-5/h2-4H,1H3

InChI key

RMEDXVIWDFLGES-UHFFFAOYSA-N

Looking for similar products? Visit Product Comparison Guide

Application

Methyl 6-chloropyridine-3-carboxylate can be used to synthesize fluoro substituted 6-phenylnicotinamide, which shows TRPV1 antagonist potency. It can also be used in the synthesis of retinoid x receptor (RXR) ligands, which have many clinical applications.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H317,H319

Hazard Classifications

Eye Irrit. 2 - Skin Sens. 1

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
MKCS3111
MKBZ9276V
MKBG7071V
MKBC5839
MKBB7853

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

"Replacing alkyl sulfonamide with aromatic sulfonamide in sulfonamide-type RXR agonists favors switch towards antagonist activity"
Morishita I-K, et al.
Bioorganic & Medicinal Chemistry, 19(03), 1001-1003 (2009)
"Design and synthesis of 6-phenylnicotinamide derivatives as antagonists of TRPV1"
Westaway.MS, et al.
Bioorganic & Medicinal Chemistry, 18(20), 5609-5613 (2008)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service