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276375

Sigma-Aldrich

1,5-Naphthalenedisulfonic acid tetrahydrate

97%

Synonym(s):

Armstrong’s acid

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About This Item

Linear Formula:
C10H6(SO3H)2·4H2O
CAS Number:
211366-30-2
Molecular Weight:
360.36
EC Number:
201-317-9
MDL number:
MFCD00149265
UNSPSC Code:
12352100
PubChem Substance ID:
24856706
NACRES:
NA.22

Assay

97%

form

solid

functional group

sulfonic acid

SMILES string

O.O.O.O.OS(=O)(=O)c1cccc2c(cccc12)S(O)(=O)=O

InChI

1S/C10H8O6S2.4H2O/c11-17(12,13)9-5-1-3-7-8(9)4-2-6-10(7)18(14,15)16;;;;/h1-6H,(H,11,12,13)(H,14,15,16);4*1H2

InChI key

ZLBLYGIIADHDKG-UHFFFAOYSA-N

General description

1,5-Naphthalenedisulfonic acid tetrahydrate reacts with [n-Bu2SnO]n in a 1:1 stoichiometry followed by reaction with 2,2′-bipyridine-N,N′-dioxide (BPDO-I) to yield 1D-coordination polymer, [n-Bu2Sn(BPDO-I)(1,5-C10H6(SO3)2)]n.

Application



  • Assessment of verapamil in a myotonic dystrophy model: Research demonstrated verapamil′s efficacy in mitigating chloride and calcium channel dysfunctions in a myotonic dystrophy mouse model, suggesting its potential in treating related muscular dystrophies (Cisco et al., 2024).


  • Cardiac tissue modeling with verapamil: Verapamil hydrochloride was tested using human-induced pluripotent stem cell-derived cardiac tissues to evaluate drug interactions and cardiac responses, proving essential for advancing cardiac safety pharmacology (Miyagawa et al., 2024).




Pictograms

Corrosion
GHS05

Signal Word

Danger

Hazard Statements

H314

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1B

Storage Class Code

8A - Combustible corrosive hazardous materials

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Vadapalli Chandrasekhar et al.
Dalton transactions (Cambridge, England : 2003), 40(1), 114-123 (2010-11-19)
The reaction of [n-Bu(2)SnO](n) with 1,5-naphthalenedisulfonic acid tetrahydrate in a 1:1 stoichiometry followed by reaction with 2,2'-bipyridine-N,N'-dioxide (BPDO-I) afforded a 1D-coordination polymer [n-Bu(2)Sn(BPDO-I)(1,5-C(10)H(6)(SO(3))(2))](n) (1) where the disulfonate ligand acts as a bridging ligand between two tin centers. An analogous reaction

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