The stability of this product in solution has not been evaluated. However, various sources suggest that aqueous solutions containing 5% detrose are stable at room temperature for up to 6 hours and refrigerated for 24 hours. Stock solutions in phosphate buffered saline may be stored in aliquots at -70 °C. However, no time frame is provided.
O9512
Oxaliplatin
powder
Synonym(s):
[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N′)[ethanedioata(2--)-O,O’]platinum
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All Photos(2)
About This Item
Empirical Formula (Hill Notation):
C8H14N2O4Pt
CAS Number:
Molecular Weight:
397.29
MDL number:
UNSPSC Code:
12352200
PubChem Substance ID:
NACRES:
NA.77
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form
powder
originator
Sanofi Aventis
storage temp.
2-8°C
SMILES string
O=C1O[Pt]OC1=O.N[C@@H]2CCCC[C@H]2N
InChI
1S/C6H14N2.C2H2O4.Pt/c7-5-3-1-2-4-6(5)8;3-1(4)2(5)6;/h5-6H,1-4,7-8H2;(H,3,4)(H,5,6);/q;;+2/p-2/t5-,6-;;/m1../s1
InChI key
ZROHGHOFXNOHSO-BNTLRKBRSA-L
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Application
Oxaliplatin has been used:
Biochem/physiol Actions
Oxaliplatin a platinum analogue, causes DNA damage and cell death by binding to DNA and forming inter and intrastrand crosslinks preventing replication and transcription.[1] Oxaliplatin is an anti-tumor agent with activity against colorectal cancer; cytotoxicity follows the formation of adducts with DNA. Oxaliplatin is an approved drug for treating colorectal cancer.[4] It is an active ingredient in FOLFOX (Folinic acid:5-FU:oxaliplatin in the ratio 1:10:1 of micromolar concentrations respectively).[3][5] Oxaliplatin causes both acute and chronic neurotoxicity in patients in a dose dependent manner and is reversible either by reducing or stopping the drug.[4]
Features and Benefits
This compound is a featured product for ADME Tox and Apoptosis research. Discover more featured ADME Tox and Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Sanofi Aventis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Carc. 2 - Eye Dam. 1 - Lact. - Muta. 2 - Repr. 1B - Resp. Sens. 1B - Skin Sens. 1 - STOT RE 1
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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The Lancet. Oncology, 14(12), 1208-1215 (2013-10-15)
Previous results of the EORTC intergroup trial 40983 showed that perioperative chemotherapy with FOLFOX4 (folinic acid, fluorouracil, and oxaliplatin) increases progression-free survival (PFS) compared with surgery alone for patients with initially resectable liver metastases from colorectal cancer. Here we present
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How long is Oxaliplatin stable when its dissolved in water? What is the recommended storage condition (temp etc) after its been dissolved in water?
1 answer-
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What is the solubility of Product O9512, Oxaliplatin in DMSO?
1 answer-
The solubility of this product in DMSO has not been determined. Various sources report that this compound is soluble at 100 mM in DMSO. However, there are several publications regarding the degradation of platinum-based compounds in DMSO when added to aqueous solutions. Please see the link below to review:
https://pmc.ncbi.nlm.nih.gov/articles/PMC4153432/Helpful?
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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What is the solubility of Product O9512, Oxaliplatin?
1 answer-
Sigma-Aldrich tests solubility of Product O9512, Oxaliplatin, in water at a concentration of 5 mg/ml. For complete dissolution, heating to 45 °C and sonication for 10 minutes may be required.
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