Skip to Content
Merck
All Photos(3)

Key Documents

P1152

Sigma-Aldrich

Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide

greener alternative

Ala:Glu:Lys:Tyr (6:2:5:1), mol wt 20,000-30,000

Synonym(s):

(L-Ala, L-Glu, L-Lys, L-Tyr)n ·HBr, COP-1

Sign Into View Organizational & Contract Pricing


About This Item

CAS Number:
MDL number:
UNSPSC Code:
12352202
NACRES:
NA.26

form

powder

Quality Level

feed ratio

Ala:Glu:Lys:Tyr (6:2:5:1)

mol wt

20,000-30,000

greener alternative product score

old score: 56
new score: 39
Find out more about DOZN™ Scoring

greener alternative product characteristics

Designing Safer Chemicals
Safer Solvents and Auxiliaries
Reduce Derivatives
Learn more about the Principles of Green Chemistry.

sustainability

Greener Alternative Product

color

white to off-white

greener alternative category

storage temp.

−20°C

InChI

1S/C9H11NO3.C6H14N2O2.C5H9NO4.C3H7NO2/c10-8(9(12)13)5-6-1-3-7(11)4-2-6;7-4-2-1-3-5(8)6(9)10;6-3(5(9)10)1-2-4(7)8;1-2(4)3(5)6/h1-4,8,11H,5,10H2,(H,12,13);5H,1-4,7-8H2,(H,9,10);3H,1-2,6H2,(H,7,8)(H,9,10);2H,4H2,1H3,(H,5,6)/t8-;5-;3-;2-/m0000/s1

InChI key

YLOCGHYTXIINAI-XKUOMLDTSA-N

General description

We are committed to bringing you Greener Alternative Products, which adhere to one of the four categories of Greener Alternatives . This product belongs to category of Re-engineered products, showing key improvements in Green Chemistry Principles “Designing Safer Chemicals”, "Safer Solvents and Auxiliaries" and “Reduce Derivatives”. Click here to view its DOZN scorecard.

Biochem/physiol Actions

Poly(Ala, Glu, Lys, Tyr) 6:2:5:1 hydrobromide is a polyamino acid reported to have a suppressive effect on allergic encephalomyelitis.
Reported to have suppressive effect on experimental allergic encephalomyelitis induced in laboratory animals.

Analysis Note

Reported molecular weight based on viscosity.

Other Notes

For additional technical information on polyamino acids please visit the Polyamino acid FAQ resource.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Suppression of experimental allergic encephalomyelitis by a synthetic polypeptide.
D Teitelbaum et al.
European journal of immunology, 1(4), 242-248 (1971-08-01)
R Aharoni et al.
Immunology letters, 58(2), 79-87 (1997-07-01)
Graft-versus-host disease (GVHD), which occurs when donor T-cells recognize multiple minor host histocompatibility antigens as non-self, presents the major limitation to successful allogeneic bone-marrow transplantation. The synthetic random copolymer of the amino acids, L-Glu, L-Lys, L-Ala and L-Tyr, termed GLAT
Neurodegeneration and neuroprotection in glaucoma: development of a therapeutic neuroprotective vaccine: the Friedenwald lecture.
Michal Schwartz
Investigative ophthalmology & visual science, 44(4), 1407-1411 (2003-03-27)
M Sela
Applied biochemistry and biotechnology, 83(1-3), 63-70 (2000-05-29)
The conformation of a peptide defines its antigenic specificity. In most cases, a free peptide is in a random form, whereas the same peptide within a protein has a defined conformation. Immunological cross-reactions between the two are rare. Nevertheless, there
S D Lytton et al.
Parasite immunology, 15(8), 489-492 (1993-08-01)
The ability of Leishmania mexicana amazonensis to inhibit antigen specific T-cell proliferation against a non-parasite polypeptide antigen, poly(LTyr, LGlu)-poly(DLAla)--poly(LLys), was examined. Infection of mouse peritoneal macrophages by promastigotes blocked the proliferation of the T-cell line, TPB1. This effect was correlated

Articles

Humankind has utilized protein materials throughout its existence, starting with the use of materials such as wool and silk for warmth and protection from the elements and continuing with the use of recombinant DNA techniques to synthesize proteins with unique and useful properties.

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service