M5435

6-Methyl-2-(phenylethynyl)pyridine hydrochloride

≥98% (HPLC)

• Synonym(s): MPEP hydrochloride
• Empirical Formula (Hill Notation): C₁₄H₁₁N · HCl
• CAS Number: 219911-35-0
• Molecular Weight: 229.70
• MDL number: MFCD02262119
• UNSPSC Code: 12352200
• PubChem Substance ID: 24278557
• NACRES: NA.77

Properties

• Assay: ≥98% (HPLC)
• form: powder
• color: off-white to light tan
• solubility: DMSO: 10 mg/mL, clear
• storage temp.: room temp
• SMILES string: Cl.Cc1cccc(n1)C#Cc2ccccc2
• InChI: 1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
• InChI key: PKDHDJBNEKXCBI-UHFFFAOYSA-N
• Gene Information: human ... GRIN2B(2904) , GRM5(2915) ; rat ... Grm5(24418)

Description

General description

GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) codes for N-methyl d-aspartate receptor subtype 2B (GluN2B). It belongs to the N-methyl-D-aspartate receptor (NMDAR) gene family. It is located on chromosome 12p13.1.

Application

6-Methyl-2-(phenylethynyl)pyridine hydrochloride has been used to investigate whether 3, 4 (±) methylenedioxymethamphetamine (MDMA) could influence self-renewal via the mGlu5 receptor in mouse embryonic stem cells (mESCs).

Biochem/physiol Actions

GRIN2B (glutamate ionotropic receptor NMDA type subunit 2B) plays an important role in the growth of neurons and is highly essential for learning and memory. GRIN2B mutation is associated with neuropsychiatric and developmental disorders like schizophrenia, Parkinson′s disease and bipolar disorder. MPEP (2-methyl-6-(phenylethynyl)pyridine hydrochloride) is used to treat Alzheimer′s disease (AD).

Highly selective, non-competitive mGluR₅ metabotropic glutamate receptor antagonist.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves