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Key Documents

05-149

Sigma-Aldrich

Anti-FGFR1 Antibody, clone 19B2

clone 19B2, Upstate®, from mouse

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

mouse

Quality Level

100

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

19B2, monoclonal

species reactivity

human, rat

manufacturer/tradename

Upstate®

technique(s)

immunoprecipitation (IP): suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NM_015850.3
NM_023105.2
NM_023106.2
NM_023107.2
NM_023108.2
NM_023110.2
NM_023111.2

UniProt accession no.

P11362

shipped in

wet ice

target post-translational modification

unmodified

Gene Information

human ... FGFR1(2260)

Specificity

extra cellular domain for both (alpha and beta) human FGF receptor

Immunogen

E. coli fusion protein corresponding to amino acids 23-325 of human FGF receptor beta (Flg)

Application

Anti-FGFR1 Antibody, clone 19B2 detects level of FGFR1 & has been published & validated for use in IP & WB.
Research Category
Signaling
Research Sub Category
Growth Factors & Receptors

Quality

routinely evaluated in sFGFR-1 (obtained from Alexis Biochemicals, Catalog # SFC-015)

Target description

110 kDa

Physical form

0.1M Tris-glycine, pH 7.4, 0.15M NaCl containing 0.05% sodium azide
Format: Purified
Protein G Chromatography

Storage and Stability

2 years at -20°C or 2 months at 4°C

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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J Z Hou et al.
Science (New York, N.Y.), 251(4994), 665-668 (1991-02-08)
Changes in heparin-binding fibroblast growth factor gene expression and receptor phenotype occur during liver regeneration and in hepatoma cells. The nucleotide sequence of complementary DNA predicts that three amino-terminal domain motifs, two juxtamembrane motifs, and two intracellular carboxyl-terminal domain motifs
Suppression of fibroblast growth factor receptor signaling inhibits pancreatic cancer growth in vitro and in vivo.
M Wagner, M E Lopez, M Cahn, M Korc
Gastroenterology null
Y Mazaki et al.
Molecular biology of the cell, 12(3), 645-662 (2001-03-17)
Paxillin acts as an adaptor protein in integrin signaling. We have shown that paxillin exists in a relatively large cytoplasmic pool, including perinuclear areas, in addition to focal complexes formed at the cell periphery and focal adhesions formed underneath the
X Guillonneau et al.
Molecular biology of the cell, 9(10), 2785-2802 (1998-10-08)
Fibroblast growth factors (FGF) 1 and 2 and their tyrosine kinase receptor (FGFR) are present throughout the adult retina. FGFs are potential mitogens, but adult retinal cells are maintained in a nonproliferative state unless the retina is damaged. Our work
Expression of a dominant negative FGF receptor inhibits axonal growth and FGF receptor phosphorylation stimulated by CAMs
Saffell, J. L., et al
Neuron, 18, 231-242 (1997)
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