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N7382

Sigma-Aldrich

Nitrosomorpholine

Synonym(s):

NMOR

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About This Item

Empirical Formula (Hill Notation):
C4H8N2O2
CAS Number:
59-89-2
Molecular Weight:
116.12
MDL number:
MFCD00039710
UNSPSC Code:
41116105
PubChem Substance ID:
24897824
NACRES:
NA.25

form

solid

Quality Level

100

SMILES string

O=NN1CCOCC1

InChI

1S/C4H8N2O2/c7-5-6-1-3-8-4-2-6/h1-4H2

InChI key

ZKXDGKXYMTYWTB-UHFFFAOYSA-N

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Biochem/physiol Actions

Tumor initiator in rodent liver, trachea, nasal cavity, esophagus, kidney, lung, and thyroid.

Packaging

Bulk package

Pictograms

Skull and crossbonesHealth hazard
GHS06,GHS08

Signal Word

Danger

Hazard Statements

H301,H351

Hazard Classifications

Acute Tox. 3 Oral - Carc. 2

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

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W Lijinsky et al.
Carcinogenesis, 3(8), 911-915 (1982-01-01)
A comparison was made of the carcinogenic effectiveness of some cyclic nitrosamines containing oxygen in the ring. The compounds were administered to F344 rats at approximately equimolar concentrations in drinking water. Nitrosomorpholine, nitroso-1,3-oxazolidine and nitrosotetrahydro-1,3-oxazine were of similar potency and
Pinar Erkekoglu et al.
Toxicology mechanisms and methods, 20(2), 45-52 (2010-01-27)
Nitrites are ubiquitous environmental contaminants present in drinking water and foods. Nitrosamines can be formed endogenously from nitrate and nitrite and secondary amines or may be present in food, tobacco smoke, and drinking water. The major goal of this work
Wolf D Kuhlmann et al.
International journal of experimental pathology, 87(5), 343-359 (2006-09-13)
Adult hepatocytes and liver-cell progenitors play a role in restoring liver tissue after injury. For the study of progenitor cells in liver repair, experimental models included (a) surgical removal of liver tissue by partial hepatectomy; (b) acute injury by carbontetrachloride;
M Tatsuta et al.
Cancer letters, 119(1), 109-113 (2008-04-01)
The effects of prolonged administration of the diuretic amiloride on hepatocarcinogenesis induced by N-nitrosomorpholine (NNM) and the labeling index of the liver were investigated in male Sprague-Dawley rats. Rats were given drinking water containing NNM for 8 weeks and received
Jutta Groos et al.
Toxicological sciences : an official journal of the Society of Toxicology, 99(2), 446-454 (2007-07-20)
Within the scope of the Rat Liver Foci Bioassay the model carcinogens N-nitrosomorpholine (NNM), 2-acetylaminoflouren (2-AAF), phenobarbital (PB), and clofibrate (CF) were analyzed concerning their potency and dose-response relationship to induce foci of altered hepatocytes (FAHs), which are known to
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