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L7414

Sigma-Aldrich

N-Lauroylsarcosine sodium salt solution

20%, for molecular biology

Synonym(s):

Sarcosyl, Sarkosyl NL, Sodium N-dodecanoyl-N-methylglycinate, Sodium N-lauroylsarcosinate solution

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About This Item

Linear Formula:
CH3(CH2)10CON(CH3)CH2COONa
CAS Number:
137-16-6
Molecular Weight:
293.38
Beilstein:
5322974
MDL number:
MFCD00042728
UNSPSC Code:
12161900
PubChem Substance ID:
24896478
NACRES:
NA.25
Pricing and availability is not currently available.

grade

for molecular biology

Quality Level

200

description

anionic

mol wt

293.38 g/mol

concentration

19-21% (Titration by HClO4)
20%

foreign activity

DNase, RNase, and protease, none detected

SMILES string

[Na+].CCCCCCCCCCCC(=O)N(C)CC([O-])=O

InChI

1S/C15H29NO3.Na/c1-3-4-5-6-7-8-9-10-11-12-14(17)16(2)13-15(18)19;/h3-13H2,1-2H3,(H,18,19);/q;+1/p-1

InChI key

KSAVQLQVUXSOCR-UHFFFAOYSA-M

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General description

N-Lauroylsarcosine sodium salt solution is an anionic surfactant which can be used in DNA extraction. [1]

Application

N-Lauroylsarcosine sodium salt has been used in a study to assess the mechanisms underlying surfactant-induced itching. [2] It has also been used in a study to investigate the formation of pH-responsive, stable vesicles resulting from an interaction with N-cetylpyridinium chloride (CPC) and N-dodecylpyridinium chloride (DPC) in aqueous mixtures. [3]

Features and Benefits

N-Lauroylsarcosine does not precipitate and is commonly used in place of SDS.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H319

Precautionary Statements

P305 + P351 + P338

Hazard Classifications

Eye Irrit. 2

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

512.6 °F

Flash Point(C)

267 °C

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Certificates of Analysis (COA)

Lot/Batch Number
0000400968
0000400967
0000400967
0000400968
0000312939

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Interaction of sodium N-lauroylsarcosinate with N-alkylpyridinium chloride surfactants: Spontaneous formation of pH-responsive, stable vesicles in aqueous mixtures
Ghosh, S. and J. Dey
Journal of Colloid and Interface Science, 358, 9-9 (2011)
Alejandro Álvarez-Quilón et al.
Nature communications, 11(1), 910-910 (2020-02-16)
The ATM kinase is a master regulator of the DNA damage response to double-strand breaks (DSBs) and a well-established tumour suppressor whose loss is the cause of the neurodegenerative and cancer-prone syndrome Ataxia-Telangiectasia (A-T). A-T patients and Atm-/- mouse models
Luoquan Li et al.
ACS sensors, 4(5), 1299-1305 (2019-05-03)
Droplet microfluidics-based platform (Drop-seq) has been shown to be a powerful tool for single cell expression profiling. Nevertheless, this platform required the simultaneous encapsulation of single cell and single barcoded bead, the incidence of which was very low, limiting its
Takahiro Sekikawa et al.
New biotechnology, 29(1), 139-143 (2011-09-20)
Detection of low amounts of Cryptosporidium oocysts in raw water sources is considered an important component in the management, prevention and control of Cryptosporidium in drinking water supplies as Cryptosporidium causes massive waterborne outbreaks worldwide. As Cryptosporidium has a robust
Yoshihiro Inami et al.
Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan, 132(11), 1225-1230 (2012-11-06)
The primary function of surfactants is to remove dirt, exfoliated corneum cells, and microorganisms from the skin. However, the use of toiletries such as soaps and shampoos containing surfactants may cause adverse effects such as cutaneous irritation, dryness, and itching.
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Questions

1–4 of 4 Questions  

  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer

    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf

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  2. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer

    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

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  3. looking for the same product but in powder form.

    1 answer

    1. Recommended: L9150 N-Lauroylsarcosine sodium salt

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  4. Can I use this product in cell lysis? ( For chromatin immunoprecipitation ).

    1 answer

    1. This item has not been specifically tested for use in cell lysis for chromatin immunoprecipitation. However, a brief search of the literature indicates this product has been used successfully in this application. Please see the citation below for more information:
      Loubiere V, Delest A, Schuettengruber B, Martinez AM, Cavalli G. Chromatin Immunoprecipitation Experiments from Whole Drosophila Embryos or Larval Imaginal Discs. Bio Protoc. 2017 Jun 5;7(11):e2327. doi: 10.21769/BioProtoc.2327. PMID: 34541088; PMCID: PMC8410254.

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