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F1016

Sigma-Aldrich

Fenoterol hydrobromide

Synonym(s):

2-(3,5-Dihydroxyphenyl)-2-hydroxy-2′-(4-hydroxyphenyl)-1′-methyldiethylamine hydrobromide

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About This Item

Empirical Formula (Hill Notation):
C17H21NO4 · HBr
CAS Number:
1944-12-3
Molecular Weight:
384.26
EC Number:
217-742-8
MDL number:
MFCD00079288
UNSPSC Code:
41116107
PubChem Substance ID:
24278431
NACRES:
NA.77

originator

Boehringer Ingelheim

SMILES string

Br[H].CC(Cc1ccc(O)cc1)NCC(O)c2cc(O)cc(O)c2

InChI

1S/C17H21NO4.BrH/c1-11(6-12-2-4-14(19)5-3-12)18-10-17(22)13-7-15(20)9-16(21)8-13;/h2-5,7-9,11,17-22H,6,10H2,1H3;1H

InChI key

SGZRQMALQBXAIQ-UHFFFAOYSA-N

Gene Information

human ... ADRB2(154)

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General description

Fenoterol hydrobromide is a sympathomimetic drug. It is used to treat asthma, bronchitis and emphysema. Fenoterol administration might be linked to liver damage. It has anti-inflammatory effects on eosinophil function.

Application

Fenoterol hydrobromide has been used in chromatography-tandem mass spectrometry (LC&-MS-MS) for specific and sensitive detection of β-agonists (BAG).

Biochem/physiol Actions

β2-adrenoceptor agonist; bronchodilator.

Features and Benefits

This compound was developed by Boehringer Ingelheim. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pictograms

Exclamation mark
GHS07

Signal Word

Warning

Hazard Statements

H302

Precautionary Statements

P301 + P312 + P330

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Rajib K Paul et al.
The Journal of pharmacology and experimental therapeutics, 343(1), 157-166 (2012-07-11)
Inhibition of cell proliferation by fenoterol and fenoterol derivatives in 1321N1 astrocytoma cells is consistent with β(2)-adrenergic receptor (β(2)-AR) stimulation. However, the events that result in fenoterol-mediated control of cell proliferation in other cell types are not clear. Here, we
Dorota Latek et al.
Journal of molecular modeling, 17(9), 2353-2366 (2011-03-03)
Cannabinoid and adrenergic receptors belong to the class A (similar to rhodopsin) G protein coupled receptors. Docking of agonists and antagonists to CB(1) and CB(2) cannabinoid receptors revealed the importance of a centrally located rotamer toggle switch and its possible
Bart G J Dekkers et al.
The Journal of pharmacology and experimental therapeutics, 342(3), 780-787 (2012-06-12)
Airway remodeling, including increased airway smooth muscle (ASM) mass and contractility, contributes to increased airway narrowing in asthma. Increased ASM mass may be caused by exposure to mitogens, including platelet-derived growth factor (PDGF) and collagen type I, which induce a
Oxford Dictionary of Medicines, Jan Hawthorn, 2003: Oxford Dictionary of Medicines (2003)
Lawrence Toll et al.
Molecular pharmacology, 81(6), 846-854 (2012-03-22)
G protein-coupled receptors (GPCRs) are integral membrane proteins that change conformation after ligand binding so that they can transduce signals from an extracellular ligand to a variety of intracellular components. The detailed interaction of a molecule with a G protein-coupled
View All Related Papers

Chromatograms

application for HPLC

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