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07-674

Sigma-Aldrich

Anti-Na+K+ ATPase α-2 Antibody

serum, Upstate®

Synonym(s):

Anti-Anti-DEE98, Anti-Anti-FARIMPD, Anti-Anti-FHM2, Anti-Anti-MHP2

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About This Item

UNSPSC Code:
12352203
eCl@ss:
32160702
NACRES:
NA.41

biological source

rabbit

Quality Level

100

antibody form

serum

antibody product type

primary antibodies

clone

polyclonal

species reactivity

rat

manufacturer/tradename

Upstate®

technique(s)

western blot: suitable

isotype

IgG

NCBI accession no.

NM_000702.2

UniProt accession no.

P50993

shipped in

dry ice

target post-translational modification

unmodified

Gene Information

human ... ATP1A2(477)

Specificity

Na+/K+ ATPase α-2
Predicted to crossreact with human, mouse, dog and monkey based on sequence homology.

Immunogen

KLH-conjugated, synthetic peptide (CKAGQENISVSKRDT) corresponding to amino acids 432-445 of human Na+K+ ATPase α-2, with an N-terminal cysteine added for conjugation purposes.

Application

Anti-Na+K+ ATPase α-2 Antibody is an antibody against Na+K+ ATPase α-2 for use in WB.
Research Category
Neuroscience
Research Sub Category
Ion Channels & Transporters

Quality

Routinely evaluated by immunoblot with rat brain microsomal preparation (catalog# 12-144)

Target description

Mr 105kDa

Physical form

Antiserum

Storage and Stability

Stable for 2 years at -20°C from date of shipment

Legal Information

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

12 - Non Combustible Liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Na(+), K(+)-ATPase: the new face of an old player in pathogenesis and apoptotic/hybrid cell death.
Yu, Shan Ping
Biochemical Pharmacology, 66, 1601-1609 (2003)
Post-ischemic stimulation of 2-deoxyglucose uptake in rat myocardium: role of translocation of Glut-4
Montessuit, C, et al
Journal of Molecular and Cellular Cardiology, 30, 393-403 (1998)
K Taniguchi et al.
Journal of biochemistry, 129(3), 335-342 (2001-02-28)
Since the discovery of Na/K-ATPase, evidence has accumulated to suggest that 1 mol of ATP hydrolysis occurs via the Na(+)-occluded ADP-sensitive phosphoenzyme, the K(+)-sensitive phosphoenzyme and the K(+)-occluded enzyme accompanying active transport of 3Na(+) and 2K(+) according the Post-Albers scheme.
The Na, K-ATPase in the failing human heart.
Schwinger, Robert H G, et al.
Cardiovascular Research, 57, 913-920 (2003)
A Mobasheri et al.
Bioscience reports, 20(2), 51-91 (2000-08-31)
Na+, K+-ATPase is ubiquitously expressed in the plasma membrane of all animal cells where it serves as the principal regulator of intracellular ion homeostasis. Na+, K+-ATPase is responsible for generating and maintaining transmembrane ionic gradients that are of vital importance
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