536709

PAMAM dendrimer, ethylenediamine core, generation 5.0 solution

5 wt. % in methanol

• Synonym(s): Poly(amidoamine)
• Linear Formula: [NH₂(CH₂)₂NH₂]:(G=5);dendri PAMAM(NH₂)₁₂₈
• CAS Number: 163442-68-0
• Molecular Weight: 28824.81
• MDL number: MFCD00197936
• UNSPSC Code: 12162002
• NACRES: NA.23

Properties

• description: amino surface groups
• form: liquid
• mol wt: generation 5.0
• feature: core type ethylenediamine core (2-carbon core)
• concentration: 5 wt. % in methanol
• no. Surface Groups: 128
• density: 0.797 g/mL at 25 °C
• storage temp.: 2-8°C

Description

General description

PAMAM dendrimers are water-soluble, non-immunogenic, and biocompatible symmetrical polymers. They possess a large quantity of modifiable terminal functional groups that can bind to various targeting or guest molecules. These terminal groups are used to covalently attach drugs, targeting ligands, or imaging agents for targeted delivery, controlled release, or imaging applications.

Application

• Synthesis of beta-Cyclodextrin-Decorated Dendritic Compounds Based on EDTA Core: This study presents an alternative to the ethylenediamine core in PAMAM dendrimers, using an EDTA core instead, providing insights into modifications that affect the dendrimers properties (Gonzalez Mendez et al., 2022).


• New Advances in General Biomedical Applications of PAMAM Dendrimers: Discusses the composition variations of PAMAM dendrimer cores, including ethylenediamine, and their implications on biomedical applications (Araujo et al., 2018).


• Poly (amidoamine) Dendrimers: Covalent and Supramolecular Synthesis: This paper reviews various synthetic strategies for PAMAM dendrimers, emphasizing the role of the ethylenediamine core in their structural formation (Lyu et al., 2019).


• Modified Carboxyl-Terminated PAMAM Dendrimers as a Cytocompatible Nano Based Drug Delivery System: Examines the biocompatibility and drug delivery efficiency of modified PAMAM dendrimers, highlighting the cores critical role (Vu et al., 2019).


• Use of Polyaminoamide Dendrimers Starting from Different Core-Initial Molecules for Inhibition of Silica Scale: This study explores the use of ethylenediamine-core PAMAM dendrimers in industrial applications, particularly for silica scale inhibition (Sun et al., 2021).

Physical form

Contains 128 surface primary amino groups.

Legal Information

Manufactured by Dendritech^®, Inc.

Dendritech is a registered trademark of Dendritech, Inc.

Safety Information

• Pictograms: GHS02,GHS06,GHS08
• Signal Word: Danger
• Hazard Statements: H225,H301 + H311 + H331,H370
• Precautionary Statements: P210 - P280 - P301 + P310 + P330 - P302 + P352 + P312 - P304 + P340 + P311
• Hazard Classifications: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
• Target Organs: Eyes
• Storage Class Code: 3 - Flammable liquids
• WGK: WGK 3
• Flash Point(F): 49.5 °F - closed cup - Methanol
• Flash Point(C): 9.7 °C - closed cup - Methanol