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Key Documents

SAB5201266

Sigma-Aldrich

Monoclonal Anti-Pink1 antibody produced in mouse

clone S4-15, purified immunoglobulin

Synonym(s):

Anti- BRPK, Anti-PTEN-induced putative kinase protein 1, Anti-Parkinson disease (autosomal recessive) 6

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About This Item

UNSPSC Code:
12352203
NACRES:
NA.41

biological source

mouse

Quality Level

100

conjugate

unconjugated

antibody form

purified immunoglobulin

antibody product type

primary antibodies

clone

S4-15, monoclonal

form

buffered aqueous solution

mol wt

antigen predicted mol wt 50 kDa

species reactivity

rat, mouse, human

concentration

1 mg/mL

technique(s)

immunocytochemistry: suitable
immunohistochemistry: suitable
western blot: suitable

isotype

IgG1

NCBI accession no.

NP_115785.1

UniProt accession no.

Q9BXM7

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... PINK1(65018)

General description

PTEN induced kinase 1 (PINK1), a serine/threonine kinase localizes to mitochondria. It comprises an N-terminal mitochondrial targeting sequence, C-terminal kinase domain, and a transmembrane anchor region. The PINK1 gene is mapped to human chromosome 1p36.12.

Immunogen

Fusion protein amino acids 112-496 (cytoplasmic C-terminus) of human PINK1. 82% identical to rat and 81% identical to mouse. >30% identity with DMPK.

Biochem/physiol Actions

PTEN induced kinase 1 (PINK1) participates in mitochondrial component biogenesis. It mediates the translation of mitochondrial respiratory chain subunits encoding nuclear mRNAs. The kinase domain region of PINK1 gene harbors most of the mutations. Mutations in the PINK1 gene are implicated in early-onset Parkinson′s disease (PD). The accumulation of PINK1 in dysfunctional mitochondria marks them for degradation. PINK1 is also implicated in the pathophysiology of cancer, diabetes, and pulmonary fibrosis.

Features and Benefits

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Physical form

PBS pH 7.4, 50% glycerol, 0.1% sodium azide

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Francesco Brunelli et al.
Mechanisms of ageing and development, 189, 111277-111277 (2020-06-07)
Extensive studies on PINK1, whose mutations are a confirmed cause of Parkinson's disease (PD), have been conducted in animal models or immortalized cell lines. These include initial ground-breaking discoveries on mitophagy, which demonstrated that PINK1 recruits Parkin on depolarized mitochondria
Mutation Analysis of Consanguineous Moroccan Patients with Parkinson's Disease Combining Microarray and Gene Panel.
Bouhouche, et al.
Frontiers in Neurology, 8, 567-567 (2020)
Alicia M Pickrell et al.
Neuron, 85(2), 257-273 (2015-01-23)
Understanding the function of genes mutated in hereditary forms of Parkinson's disease yields insight into disease etiology and reveals new pathways in cell biology. Although mutations or variants in many genes increase the susceptibility to Parkinson's disease, only a handful

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