D6140

Demeclocycline hydrochloride

powder or crystals, suitable for cell culture

• Synonym(s): 7-Chloro-6-demethyltetracycline hydrochloride, Demethylchlorotetracycline hydrochloride
• Empirical Formula (Hill Notation): C₂₁H₂₁ClN₂O₈ · HCl
• CAS Number: 64-73-3
• Molecular Weight: 501.31
• Beilstein: 3849198
• EC Number: 200-592-2
• MDL number: MFCD00082371
• UNSPSC Code: 12352207
• PubChem Substance ID: 24278380
• NACRES: NA.75

Properties

• product name: Demeclocycline hydrochloride, powder or crystals
• Assay: 89.5-102.0% anhydrous basis
• Quality Level: 200
• form: powder or crystals
• technique(s): cell culture | mammalian: suitable
• solubility: soluble (1 mg/mL of Demeclocycline Hydrochloride in 0.01 N hydrochloric acid)
• antibiotic activity spectrum: Gram-negative bacteria; Gram-positive bacteria
• Mode of action: protein synthesis | interferes
• storage temp.: −20°C
• SMILES string: Cl[H].[H][C@]12C[C@@]3([H])[C@H](N(C)C)C(O)=C(C(N)=O)C(=O)[C@@]3(O)C(O)=C1C(=O)c4c(O)ccc(Cl)c4[C@H]2O
• InChI: 1S/C21H21ClN2O8.ClH/c1-24(2)14-7-5-6-10(16(27)12-9(25)4-3-8(22)11(12)15(6)26)18(29)21(7,32)19(30)13(17(14)28)20(23)31;/h3-4,6-7,14-15,25-26,28-29,32H,5H2,1-2H3,(H2,23,31);1H/t6-,7-,14-,15-,21-;/m0./s1
• InChI key: GVSJQNRGSCOSNJ-KBHRXELFSA-N

Description

General description

Chemical structure: tetracycline

Biochem/physiol Actions

Because it is excreted more slowly than tetracycline, it maintains effective blood levels for longer periods of time.

Demeclocycline hydrochloride is a tetracycline antibiotic derived from a strain of Streptomyces aureofaciens. DMC protects neurons from glutamate induced toxicity by suppressing calpain I and II activities.

Used to study mechanisms of bacterial protein synthesis inhibition at the level of the 30S subunit and aminoacy-tRNA A-site binding.

Safety Information

• Pictograms: GHS08,GHS07
• Signal Word: Warning
• Hazard Statements: H302 + H312 + H332,H315,H319,H335,H341
• Precautionary Statements: P280 - P301 + P312 - P302 + P352 + P312 - P304 + P340 + P312 - P305 + P351 + P338 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Dermal - Acute Tox. 4 Inhalation - Acute Tox. 4 Oral - Eye Irrit. 2 - Muta. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 2
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves