If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/449/386/product-dating-information-mk.pdf
PHR1939
Hydroxyproline
Pharmaceutical Secondary Standard; Certified Reference Material
Synonym(s):
trans-4-Hydroxy-L-proline, (2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid, Hyp
About This Item
Recommended Products
grade
certified reference material
pharmaceutical secondary standard
Quality Level
API family
proline
CofA
current certificate can be downloaded
packaging
pkg of 500 mg
mp
273 °C (dec.) (lit.)
application(s)
pharmaceutical
format
neat
storage temp.
2-30°C
SMILES string
O[C@H]1CN[C@@H](C1)C(O)=O
InChI
1S/C5H9NO3/c7-3-1-4(5(8)9)6-2-3/h3-4,6-7H,1-2H2,(H,8,9)/t3-,4+/m1/s1
InChI key
PMMYEEVYMWASQN-DMTCNVIQSA-N
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General description
Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Hydroxyproline, found exclusively in collagen, is formed from the hydroxylation of proline. It is used as a biomarker to measure the collagen content of various biological samples.
Application
- Multi-analysis of acetylcarnitine, proline, hydroxyproline, citrulline, and arginine as possible biomarkers by liquid chromatography-tandem mass spectrometry (LC-MS/MS) in human plasma samples
- Simultaneous determination of proline and hydroxyproline in plasma samples by (LC-MS/MS using a new fluorescent reagent for pre-column derivatization
- Development of a micellar electrokinetic chromatography (MEKC) method to measure hydroxyproline in various dairy products upon in-capillary derivatization
- Quantitative analysis of free prolyl dipeptides, proline, and hydroxyproline by flow-gated capillary electrophoresis combined with laser-induced fluorescence detector from unhydrolyzed urine samples[1]
Other Notes
Analysis Note
Footnote
Recommended products
Storage Class Code
11 - Combustible Solids
WGK
WGK 1
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How can I determine the shelf life / expiration / retest date of this product?
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How is shipping temperature determined? And how is it related to the product storage temperature?
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Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf
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Does the data indicate that refrigeration temperatures (2-8°C) or freezing would help maintain the stability of the amino acid standard? Additionally, is it recommended to store the powder in a desiccator to preserve its stability over time?
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There have been no indications of instability in this material in either short-term or long-term studies. Storing the material at cooler temperatures would help minimize the risk of degradation. However, it's important to note that cannot guarantee the ongoing suitability of a standard over multiple uses.
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