C-121
Carbamazepine-10,11-epoxide solution
1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®
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About This Item
Empirical Formula (Hill Notation):
C15H12N2O2
CAS Number:
Molecular Weight:
252.27
EC Number:
MDL number:
UNSPSC Code:
41116107
PubChem Substance ID:
NACRES:
NA.24
Recommended Products
grade
certified reference material
form
liquid
feature
Snap-N-Spike®/Snap-N-Shoot®
packaging
ampule of 1 mL
manufacturer/tradename
Cerilliant®
concentration
1.0 mg/mL in methanol
technique(s)
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
application(s)
clinical testing
format
single component solution
storage temp.
−20°C
SMILES string
O=C(N)N1C2=CC=CC=C2C3C(O3)C4=CC=CC=C14
InChI
1S/C15H12N2O2/c16-15(18)17-11-7-3-1-5-9(11)13-14(19-13)10-6-2-4-8-12(10)17/h1-8,13-14H,(H2,16,18)
InChI key
ZRWWEEVEIOGMMT-UHFFFAOYSA-N
General description
Carbamazepine-10,11-epoxide is the primary, active metabolite in both urine and serum of carbamazepine, an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder as well as trigeminal neuralgia. Potential toxicity of the epoxide metabolite requires regular therapeutic drug monitoring by LC or LC/MS for patients taking carbamazepine.
Application
- Advanced Analytical Techniques for Carbamazepine Epoxide: A study utilized covalent organic framework-based solid-phase microextraction coupled with electrospray ionization mass spectrometry for sensitive screening and quantitative evaluation of carbamazepine and its metabolite, Carbamazepine-10,11-epoxide, in mice, advancing biochemical research reagents and methodologies (Huang et al., 2022).
- Carbamazepine Metabolite Monitoring: Research developed an HPLC method for the determination of antiepileptic drugs including Carbamazepine-10,11-epoxide in human saliva, facilitating therapeutic drug monitoring and offering a non-invasive technique for patient compliance and drug metabolism studies (Carona et al., 2021).
- Quantitative and Qualitative Analysis of Antiepileptic Drugs: A novel capillary microsampling device, Microsampling Wing (MSW), was evaluated for its effectiveness in handling antiepileptic drugs such as Carbamazepine-10,11-epoxide in rats, enhancing drug discovery processes by providing a minimally invasive sampling method for pharmacokinetic studies (Hotta et al., 2021).
Legal Information
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
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Product No.
Description
Pricing
Signal Word
Danger
Hazard Statements
Precautionary Statements
Hazard Classifications
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
Target Organs
Eyes
Storage Class Code
3 - Flammable liquids
WGK
WGK 1
Flash Point(F)
49.5 °F - closed cup
Flash Point(C)
9.7 °C - closed cup
Certificates of Analysis (COA)
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A sensitive and reproducible stir bar-sorptive extraction and high-performance liquid chromatography-UV detection (SBSE/HPLC-UV) method for therapeutic drug monitoring of carbamazepine, carbamazepine-10,11-epoxide, phenytoin and phenobarbital in plasma samples is described and compared with a liquid:liquid extraction (LLE/HPLC-UV) method. Important factors in
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