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530301

Sigma-Aldrich

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride

97%

Synonym(s):

2-(Chloromethyl)-3,4-dimethoxypyridinium hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C8H11Cl2NO2
CAS Number:
72830-09-2
Molecular Weight:
224.08
Beilstein:
5360726
EC Number:
416-440-5
MDL number:
MFCD02181083
UNSPSC Code:
12352100
PubChem Substance ID:
24877740
NACRES:
NA.22

Quality Level

100

Assay

97%

mp

155 °C (dec.) (lit.)

SMILES string

Cl[H].COc1ccnc(CCl)c1OC

InChI

1S/C8H10ClNO2.ClH/c1-11-7-3-4-10-6(5-9)8(7)12-2;/h3-4H,5H2,1-2H3;1H

InChI key

YYRIKJFWBIEEDH-UHFFFAOYSA-N

Related Categories

General description

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride (CDP) can be synthesized using maltol as a starting material. CDP and DMS (dimethyl sulfate) are used in the preparation of pantoprazole sodium (PPS), an antiulcerative drug. The quantification of CDP and DMS in PPS can be done simultaneously by gas chromatography–mass spectrometry (GC-MS) method.

Application

2-(Chloromethyl)-3,4-dimethoxypyridine hydrochloride may be used as a precursor for the preparation [(2-pyridyl)-2-ethyl]-[3,4-dimethoxy-(2-pyridylmethyl)]-N-methylamine.

Signal Word

Danger

Precautionary Statements

P273 - P280 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 4 Dermal - Acute Tox. 4 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT RE 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Validated chromatographic methods for the determination of process related toxic impurities in pantoprazole sodium.
Raman NVVSS, et al.
Chromatographia, 68(5-6), 481-484 (2008)
fac-Cobalt (III)-azido complexes derived from substituted pyridyl-based tridentate amines.
Massoud SS, et al.
Transition Met. Chem. (London), 39(5), 585-591 (2014)
The Synthesis of 2-chloromethyl-3,4-dimethoxypyridine Hydrochloride.
L DL, et al.
Journal of Jiangxi Normal University (Natural Science Edition), 42-45 (2003)

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