MST3 (mammalian sterile 20 (Ste20)-like kinase 3) gene is mapped to human chromosome 13q32.2. The gene is ubiquitously expressed in different tissues. MST3 belongs to the subfamily of the germinal centre kinase III kinases. It is also known as serine/threonine kinase 24 (STK24). The encoded protein contains a kinase domain and a regulatory domain at the N and C-terminal, respectively. The protein includes two isoforms namely MST3a and MST3b which differ by 12 amino acids. The protein is mostly localized in the cytoplasm.
The yeast ‘Sterile 20′ gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000 [PubMed 10644707]).[supplied by OMIM]
Immunogen
MST3 (Q9Y6E0, 350-384) This antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide selected from the C-terminal region of human MST3.
Biochem/physiol Actions
MST3 (mammalian sterile 20 (Ste20)-like kinase 3) is known to be involved in the development of proper filopodia, dendritic spine, and excitatory synapse. MST3 induces outgrowth of axon and its regeneration in vivo. MST3 is associated with Caspase 3-mediated apoptosis in trophoblasts, induced by hypoxia.
Physical form
Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.
Mammalian Sterile 20 (Ste20)-like kinase 3 (MST3) is a ubiquitously expressed kinase capable of enhancing axon outgrowth. Whether and how MST3 kinase signaling might regulate development of dendritic filopodia and spine synapses is unknown. Through shRNA-mediated depletion of MST3 and
Integrated genomic and expression profiling in mantle cell lymphoma: identification of gene-dosage regulated candidate genes.
Schraders M
British Journal of Haematology, 210-221 (2008)
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