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Streptolysin O from Streptococcus pyogenes

Name: Streptolysin O from <I>Streptococcus pyogenes</I>
Brand: SIGMA

From Streptococcus pyogenes, Thiol-activated toxin, lyophilized powder

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About This Item

CAS Number:

98072-47-0

UNSPSC Code:

12352200

NACRES:

NA.77

EC Number:

308-500-3

MDL number:

MFCD00132389

Form:

lyophilized powder

Pricing and availability is not currently available.

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Properties

Product Name

Streptolysin O from Streptococcus pyogenes, γ-irradiated

biological source

Streptococcus pyogenes

Quality Segment

200

sterility

γ-irradiated

form

lyophilized powder

application(s)

cell analysis

storage temp.

2-8°C

Gene Information

Streptococcus pyogenes ... slo(900490)

Description

Application

Permeabilizes membranes to permit cellular uptake of large or charged molecules.

Streptolysin O from Streptococcus pyogenes has been used in streptolysin O (SLO) permeabilization. It has also been used to evaluate the barrier integrity and cytotoxicity of caco-2 and T84 IEC polarized monolayers.

Biochem/physiol Actions

Thiol-activated toxin that permeabilizes animal cell membranes. The protein binds as a monomer to membrane cholesterol and subsequently polymerizes into large arc- and ring-shaped structures surrounding pores of >12 nm.

Thiol-activated toxin that permeabilizes animal cell membranes..

Streptolysin O (SLO), obtained from Streptococcus pyogenes has the capability to block osteoclastogenesis, induced by receptor activator of nuclear factor κ-Β ligand (RANK) through the NF-κB signaling pathway. Streptococcus pyogenes (GAS) is a bacterial strain that results in bacterial arthritis, osteomyelitis and implant infections.

Preparation Note

Prepared from S 5265

Other Notes

One unit will cause 50% lysis of 2% red blood cell suspensions in phosphate buffered saline, pH 7.4, after incubation at 37 °C for 30 min.

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This Item	S5265	D0564	SAE0089
Sigma-Aldrich S0149 Streptolysin O from Streptococcus pyogenes	Sigma-Aldrich S5265 Streptolysin O from Streptococcus pyogenes	Sigma-Aldrich D0564 Diphtheria Toxin from Corynebacterium diphtheriae	Sigma-Aldrich SAE0089 Streptolysin O from Streptococcus pyogenes
description γ-irradiated	description lyophilized powder, Protein ~3 % by Lowry, 25,000-50,000 U/vial	description lyophilized powder, Product is in unnicked form	description ≥1,000,000 units/mg protein, recombinant, lyophilized powder, expressed in E. coli
form lyophilized powder	form lyophilized powder	form lyophilized powder	form -
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level -
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
Gene Information Streptococcus pyogenes ... slo(900490)	Gene Information Streptococcus pyogenes MGAS8232 ... slo(993428)	Gene Information -	Gene Information -
biological source Streptococcus pyogenes	biological source -	biological source -	biological source -
application(s) cell analysis	application(s) -	application(s) -	application(s) -

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pictograms

GHS06

signalword

Danger

hcodes

H300 + H310 + H330

pcodes

P262 - P280 - P301 + P310 + P330 - P302 + P352 + P310 - P304 + P340 + P310

Hazard Classifications

Acute Tox. 1 Dermal - Acute Tox. 1 Inhalation - Acute Tox. 1 Oral

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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