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H6161

Sigma-Aldrich

[Gly14]-Humanin G human

≥95% (HPLC), powder

Synonym(s):

S14G-humanin, HNG

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About This Item

MDL number:
MFCD03787971
UNSPSC Code:
12352209
NACRES:
NA.32

biological source

human

Quality Level

200

Assay

≥95% (HPLC)

form

powder

mol wt

2654.2-2660.2 Da

storage condition

(Keep container tightly closed in a dry and well-ventilated place)

technique(s)

activity assay: suitable

solubility

water: 1.00-1.04 mg/mL, clear, colorless

shipped in

dry ice

storage temp.

−20°C

Amino Acid Sequence

Met-Ala-Pro-Arg-Gly-Phe-Ser-Cys-Leu-Leu-Leu-Leu-Thr-Gly-Glu-Ile-Asp-Leu-Pro-Val-Lys-Arg-Arg-Ala

General description

Research area: Neuroscience

[Gly14]-humanin (HNG) belongs to the family of mitochondrial-derived peptides. HNG (humanin-G) is an analog of humanin, generated by S14G (serine-14-glycine) mutation. HNG shows a 1000 times stronger activity.

Application

[Gly14]-Humanin G human has been used:
  • along with bortezomib in pharmacological inhibition studies to treat mice to limit the toxic effects of bortezomib
  • to study its effect on high glucose (HG)-induced apoptosis of endothelial cells (ECs)
  • to study its neuroprotective effects in an in vitro oxygen-glucose deprivation/reoxygenation (OGD/R) model using SH-SY5Y neuroblastoma cells
[Gly¹⁴]-Humanin G human has been used to limit the toxicity during the bortezomib treatment in neonatal brachial plexus injury (NBPI) mice model. It has also been used in the cell culture of the human-derived neuroblastoma cell line.

Biochem/physiol Actions

Endogenous rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer′s disease genes and Aβ
[Gly14]-humanin (HNG) stimulates cell growth, proliferation, and cell cycle progression. It enhances proteins such as kinases, transporters, transmembrane receptors, and transcription and translational regulators. HNG exhibits intense in vitro neuroprotective effects compared to natural HN. Studies show that it is an effective cytoprotectant both in vitro and in vivo. HNG is found to prevent high glucose (HG)-induced apoptosis of endothelial cells (ECs). It is proven to inhibit AngII-induced phenotypic switch in vascular smooth muscle cells (VSMCs).

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Guangsheng Gao et al.
Neurological research, 39(10), 895-903 (2017-07-20)
Humanin (HN) has been identified to suppress neuron death. Gly Rats were randomly divided into 13 groups: Sham group, GI groups and HNG groups. Both GI group and HNG groups included six time points (1, 3, 6, 12, 24, and
Meng-Yuan Shen et al.
Diabetes, metabolic syndrome and obesity : targets and therapy, 14, 2335-2347 (2021-06-04)
Humanin, a newly emerging endogenously expressed cytoprotective peptide, has been shown to have anti-apoptotic properties effects by protecting neuronal cells injury. Endothelial microparticles (EMPs) are considered as vital mediators in intercellular communication. EMPs may regulate various physiological and pathological processes
[Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles
Shen MY, et al.
Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy, 2335-2347 (2021)
Sia Nikolaou et al.
JCI insight, 4(23) (2019-10-30)
Muscle contractures are a prominent and disabling feature of many neuromuscular disorders, including the 2 most common forms of childhood neurologic dysfunction: neonatal brachial plexus injury (NBPI) and cerebral palsy. There are currently no treatment strategies to directly alter the
HNG, a humanin analogue, promotes hair growth by inhibiting anagen-to-catagen transition
Kim SM, et al.
International Journal of Molecular Sciences, 21 (2020)
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