SML0450

5-BDBD

≥98% (HPLC), P2X4 inhibitor, powder

• Synonym(s): 5-(3-Bromophenyl)-1,3-dihydro-2H-Benzofuro[3,2-e]-1,4-diazepin-2-one
• Empirical Formula (Hill Notation): C₁₇H₁₁BrN₂O₂
• CAS Number: 768404-03-1
• Molecular Weight: 355.19
• UNSPSC Code: 12352200
• PubChem Substance ID: 329824730
• NACRES: NA.77
• MDL number: MFCD18086878
• Assay: ≥98% (HPLC)
• Form: powder

Properties

• Product Name: 5-BDBD, ≥98% (HPLC)
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 15 mg/mL (clear solution)
• storage temp.: 2-8°C
• SMILES string: Brc1cccc(c1)C2=NCC(=O)Nc3c2oc4ccccc34
• InChI: 1S/C17H11BrN2O2/c18-11-5-3-4-10(8-11)15-17-16(20-14(21)9-19-15)12-6-1-2-7-13(12)22-17/h1-8H,9H2,(H,20,21)
• InChI key: NKYMVQPXXTZHSF-UHFFFAOYSA-N

Description

Biochem/physiol Actions

5-BDBD is a specific inhibitor of P2X4.

5-BDBD is a specific inhibitor of P2X4. The compound inhibits P2X4 currents in CHO cells with an IC₅₀ of 500 nM.

In native tissues, 5-BDBD is considered as a beneficial antagonist to analyze the effect of P2X receptors (P2XRs) subtype P2X4R.

Features and Benefits

This compound is featured on the P2 Receptors: P2X Ion Channel Family page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Safety Information

• Storage Class: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable