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C0128

Sigma-Aldrich

α-Chloralose

Synonym(s):

1,2-O-(2,2,2-Trichloroethylidene)-α-D-glucofuranose, Anhydro-D-glucochloral, Chloralose

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About This Item

Empirical Formula (Hill Notation):
C8H11Cl3O6
CAS Number:
15879-93-3
Molecular Weight:
309.53
Beilstein:
85418
EC Number:
240-016-7
MDL number:
MFCD00005542
UNSPSC Code:
12352201
PubChem Substance ID:
24892236
NACRES:
NA.25
Pricing and availability is not currently available.

form

powder

impurities

≤20% β-anomer

color

white to off-white

solubility

ethanol: 10 mg/mL, clear to slightly hazy, colorless to faintly yellow (or yellow-brown)

SMILES string

OC[C@@H](O)[C@H]1O[C@@H]2O[C@@H](O[C@@H]2[C@H]1O)C(Cl)(Cl)Cl

InChI

1S/C8H11Cl3O6/c9-8(10,11)7-16-5-3(14)4(2(13)1-12)15-6(5)17-7/h2-7,12-14H,1H2/t2-,3+,4-,5-,6-,7-/m1/s1

InChI key

OJYGBLRPYBAHRT-IPQSZEQASA-N

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Application

α-Chloralose has been used as anesthetic in surgical preparations.[1][2]

Biochem/physiol Actions

α-Chloralose is used as an immobilizing agent.[3] It is mostly used in studies, which involves autonomic reflexes. α-Chloralose is a sedative hypnotic.[4] It has high significance as anesthetic for laboratory animals.[5]

Other Notes

To gain a comprehensive understanding of our extensive range of Monosaccharides for your research, we encourage you to visit our Carbohydrates Category page.

Pictograms

Skull and crossbonesEnvironment
GHS06,GHS09

Signal Word

Danger

Hazard Statements

H301,H332,H336,H410

Hazard Classifications

Acute Tox. 3 Oral - Acute Tox. 4 Inhalation - Aquatic Acute 1 - Aquatic Chronic 1 - STOT SE 3

Target Organs

Central nervous system

Storage Class Code

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

WGK

WGK 1

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
BCCK0932
BCCF1953
BCCH8687
BCCC7714
BCCC5785

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Preparation of water-soluble compounds by covalent attachment of solubilizing moieties
The Practice of Medicinal Chemistry, 767-785 (2008)
Vertebrate pest control chemicals and their use in urban and rural environments
Hayes' Handbook of Pesticide Toxicology, 271-284 (2010)
Serotonin in the solitary tract nucleus shortens the laryngeal chemoreflex in anaesthetized neonatal rats
Donnelly WT, et al.
Experimental Physiology, 101(7), 946-961 (2016)
Activation of serotonergic neurons in the medullary caudal raphe shortens the laryngeal chemoreflex in anaesthetized neonatal rats
Donnelly WT, et al.
Experimental Physiology, 102(8), 1007-1018 (2017)
Preanesthesia, anesthesia, analgesia, and euthanasia
Laboratory Animal Medicine, 1135-1200 (2015)
View All Related Papers

Questions

  1. I need to make a 10 mg/ml solution with alpha-chloralose for IV injection in experimental rats. Can I talk to someone for guidance on preparation and storage?

    1 answer

    1. This product is tested for solubility at 10mg/mL in ethanol. This solvent would not be the preferred solvent for use in animal models. This compound is not tested for in vivo use, but is a commonly utilized drug in animal studies. The following reference may be useful for this application:
      A simple method, using 2-hydroxypropyl-?-cyclodextrin, of administering ?-chloralose at room temperature
      https://www.sciencedirect.com/science/article/pii/S0165027097001106?via%3Dihub

      Preparation of Water-Soluble Compounds by Covalent Attachment of Solubilizing Moieties
      https://www.sciencedirect.com/science/article/abs/pii/B9780124172050000304

      (2-Hydroxypropyl)-?-cyclodextrin products
      https://www.sigmaaldrich.com/US/en/substance/12345128446355

      Cyclodextrin overview
      https://www.sigmaaldrich.com/US/en/technical-documents/technical-article/cell-culture-and-cell-culture-analysis/mammalian-cell-culture/cyclodextrins

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