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Key Documents

A1028

Sigma-Aldrich

8-Anilino-1-naphthalenesulfonic acid

≥97% purity (HPLC), powder

Synonym(s):

N-Phenyl peri acid, ANS, ANSA

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About This Item

Linear Formula:
C6H5NHC10H6SO3H
CAS Number:
Molecular Weight:
299.34
Beilstein:
1843887
MDL number:
UNSPSC Code:
12171500
PubChem Substance ID:
NACRES:
NA.47

product name

8-Anilino-1-naphthalenesulfonic acid,

Assay

≥97% (HPLC)

Quality Level

form

powder

composition

, <0.5% (solvent)

color

black
gray to dark green

mp

215-217 °C (dec.) (lit.)

solubility

DMF: 50 mg/mL

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

OS(=O)(=O)c1cccc2cccc(Nc3ccccc3)c12

InChI

1S/C16H13NO3S/c18-21(19,20)15-11-5-7-12-6-4-10-14(16(12)15)17-13-8-2-1-3-9-13/h1-11,17H,(H,18,19,20)

InChI key

FWEOQOXTVHGIFQ-UHFFFAOYSA-N

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Application

8-Anilino-1-naphthalenesulfonic acid (ANS) has been used to study the thermal aggregation of BSA (bovine serum albumin).

Biochem/physiol Actions

8-Anilino-1-naphthalenesulfonic acid (ANS) is an important dye which is used to study the intermediate states in the folding/unfolding pathways of proteins. It is also useful to check the conformational changes involved with the aggregation of proteins. ANS is nonfluorescent in the aqueous solution, however, it fluoresces strongly upon binding to BSA (bovine serum albumin) and denatured proteins. It is used for the detection of albumin in the serum. ANS mainly interacts with the solvent exposed nonpolar (hydrophobic) sites.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable


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Thermal aggregation of bovine serum albumin at different pH: comparison with human serum albumin.
Vetri V, et al.
European Biophysics Journal, 36, 717-717 (2007)
Uversky VN and Permiakov EA
Methods in Protein Structure and Stability Analysis (2007)
Thermal aggregation of glycated bovine serum albumin.
Rondeau P, et al.
Biochimica et Biophysica Acta, 1804, 789-789 (2010)
Nannan Chen et al.
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