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About This Item
Empirical Formula (Hill Notation):
C28H41N7O5
Molecular Weight:
555.67
UNSPSC Code:
12352202
NACRES:
NA.32
Recommended Products
Assay
≥95% (HPLC)
form
lyophilized
composition
Peptide Content, ≥80%
storage condition
protect from light
storage temp.
−20°C
Amino Acid Sequence
BOC-Val-Gly-Arg-βNA
Application
Plasminogen Activator Substrate has been used as a fluorogenic thrombin substrate to measure the fluorescence released by cleavage of the thrombin substrate to assess the functional activity of the mannose-binding lectin–mannose-associated serine protease (MBL-MASP) complex.
Plasminogen Activator is a serine protease that coverts plasminogen into plasmin. Plasminogen activator may be detected using VGR peptide substrates such a BOC-VGR-βNA and Boc-Val-Gly-Arg-AMC (VGR).
Biochem/physiol Actions
Plasminogen activator (PA) is used to cure life-threatening coronary and cerebrovascular blockages. The important role of the PA system is to convert the inactive plasminogen to plasmin. However, it also plays a vital role in embryogenesis, cell migration, wound healing, inflammatory response, and apoptotic cell death. The PA system is also involved in tumor growth, angiogenesis, tumor cell invasion, migration, and metastasis in cancer patients.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.
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Niaz Mahmood et al.
Frontiers in oncology, 8, 24-24 (2018-02-28)
The plasminogen activator (PA) system is an extracellular proteolytic enzyme system associated with various physiological and pathophysiological processes. A large body of evidence support that among the various components of the PA system, urokinase-type plasminogen activator (uPA), its receptor (uPAR)
DEPRESSION, METABOLIC SYNDROME, AND HEART DISEASE
Mendelson, Scott D
Metabolic Syndrome and Psychiatric Illness (2008)
Laura Choteau et al.
Scientific reports, 6, 29636-29636 (2016-07-13)
Mannose-binding lectin, together with mannose-associated serine proteases, activates the lectin pathway of the complement system and subsequent inflammatory mechanisms. An association between mannose-binding lectin deficiency and anti-Saccharomyces cerevisiae antibody levels is observed in Crohn's disease and this deficiency is frequently
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