G8503

18α-Glycyrrhetinic acid

≥95%

• Synonym(s): 18α-Glycyrrhetic acid, 18-Isoglycyrrhetinic acid, 3β-Hydroxy-11-oxo-18α,20β-olean-12-en-29-oic acid
• Empirical Formula (Hill Notation): C₃₀H₄₆O₄
• CAS Number: 1449-05-4
• Molecular Weight: 470.68
• EC Number: 215-907-9
• MDL number: MFCD00064897
• UNSPSC Code: 12352115
• PubChem Substance ID: 57654221
• NACRES: NA.22

Properties

• Assay: ≥95%
• SMILES string: [H][C@]12C[C@](C)(CC[C@]1(C)CC[C@]3(C)C2=CC(=O)C4[C@@]5(C)CC[C@H](O)C(C)(C)[C@]5([H])CC[C@@]34C)C(O)=O
• InChI: 1S/C30H46O4/c1-25(2)21-8-11-30(7)23(28(21,5)10-9-22(25)32)20(31)16-18-19-17-27(4,24(33)34)13-12-26(19,3)14-15-29(18,30)6/h16,19,21-23,32H,8-15,17H2,1-7H3,(H,33,34)/t19-,21+,22+,23-,26-,27+,28+,29-,30-/m1/s1
• InChI key: MPDGHEJMBKOTSU-PMTKVOBESA-N

Description

General description

18α-Glycyrrhetinic acid (18α-GA) is a bioactive triterpenoid found in licorice. It shows selective inhibition of 11-HSD1 (11-hydroxysteroid dehydrogenase 1). It also shows anti-proliferative and apoptotic effect on hepatic stellate cells (HSCs).

Application

18α-Glycyrrhetinic acid may be used to synthesize:

• 3-keto-18α-glycyrrhetinic acid
• methyl esters of 18α-glycyrrhetinic acid
• methyl esters of 3-keto-18α-glycyrrhetinic acid

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H302
• Precautionary Statements: P301 + P312 + P330
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves