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PX1235

Supelco

Piperidine

Synonym(s):

Piperidine, Hexahydropyridine

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About This Item

Empirical Formula (Hill Notation):
C5H11N
CAS Number:
110-89-4
Molecular Weight:
85.15
MDL number:
MFCD00005979
UNSPSC Code:
12191504
EC Index Number:
203-813-0

vapor pressure

34 hPa ( 20 °C)

Quality Level

200

assay

≥99.5% (GC)

form

liquid

impurities

≤0.2% Water (H2O)

color

APHA: ≤50

pH

12.6 (20 °C, 100 g/L in H2O)

bp

106 °C/1013 hPa

mp

-10.8 °C

transition temp

flash point 16 °C

density

0.86 g/cm3 at 20 °C

shipped in

ambient

storage temp.

room temp

InChI

1S/C5H11N/c1-2-4-6-5-3-1/h6H,1-5H2

InChI key

NQRYJNQNLNOLGT-UHFFFAOYSA-N

Application

Piperidine can be used as:
  • A Fmoc removal agent in solid-phase peptide synthesis.
  • An organic structure-directing agent in the synthesis of ferrierite zeolites and CoAPO (cobalt aluminophosphate) materials.
  • A reagent in the preparation of N-(2,4-dinitrophenyl)piperidine by reacting with 2,4-dinitrochlorobenzene via aromatic nucleophilic substitution reaction.

Analysis Note

Assay (GC): 99.5% min
Color (APHA): 50APHA max
Form: Clear liquid
Identity (IR-spectrum): Conforms
Water (H2O): 0.2% max

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Eye Dam. 1 - Flam. Liq. 2 - Skin Corr. 1B

Storage Class

3 - Flammable liquids

wgk_germany

WGK 1

flash_point_f

60.8 °F - closed cup

flash_point_c

16 °C - closed cup

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Thermal investigations of CoAPO materials prepared by using piperidine as a structure-directing agent
Rajic N, et al.
Thermochimica Acta, 351(1-2), 119-124 (2000)
Synthesis of FER zeolite with piperidine as structure-directing agent and its catalytic application
Chu Weifeng, et al.
Chinese Journal of Catalysis, 38(11), 1880-1887 (2017)
Solvent effects on aromatic nucleophilic substitutions. Part 3. The kinetics of the reaction of 2, 4-dinitrochlorobenzene with piperidine in aprotic solvents
Mancini PME, et al.
J. Chem. Soc. Perkin Trans. II, (7), 1133-1138 (1984)
Omar F Luna et al.
Molecules (Basel, Switzerland), 21(11) (2016-11-18)
The deprotection step is crucial in order to secure a good quality product in Fmoc solid phase peptide synthesis. 9-Fluorenylmethoxycarbonyl (Fmoc) removal is achieved by a two-step mechanism reaction favored by the use of cyclic secondary amines; however, the efficiency

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