341215
Exotoxin A, Pseudomonas aeruginosa - CAS 91262-95-2 - Calbiochem
Shown to inhibit protein synthesis through ADP-ribosylation of elongation factor 2.
Synonym(s):
Exotoxin A, Pseudomonas aeruginosa - CAS 91262-95-2 - Calbiochem
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About This Item
Recommended Products
Quality Level
form
lyophilized
manufacturer/tradename
Calbiochem®
storage condition
do not freeze
solubility
water: soluble
shipped in
ambient
storage temp.
2-8°C
General description
Shown to inhibit protein synthesis through ADP-ribosylation of elongation factor 2. Cytopathic for a number of cell lines and exhibits toxicity in animals. Has enzymatic activity identical to that of diphtheria toxin, however it has distinct target-cell specificities and is immunologically unrelated.
Shown to inhibit protein synthesis through ADP-ribosylation of elongation factor 2. Cytopathic for a number of cell lines and exhibits toxicity in animals. Has enzymatic activity identical to that of diphtheria toxin; however, it has distinct target-cell specificity and is immunologically unrelated.
Biochem/physiol Actions
Cell permeable: no
Primary Target
ADP-ribosylation of elongation factor 2
ADP-ribosylation of elongation factor 2
Product does not compete with ATP.
Reversible: no
Warning
Toxicity: Highly Toxic (H)
Physical form
Solid lyophilized from 150 mM NaCl, 10 mM sodium phosphate buffer, pH 7.5.
Reconstitution
Following reconstitution, aliquot and freeze (-20°C) for long term storage or refrigerate (4°C) for short term storage. Stock solutions are stable for up to 2 weeks at 4°C or for up to 6 months at -20°C.
Analysis Note
Single band by SDS-PAGE; single precipitin band by immunodiffusion
Other Notes
Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.
Prentice, G.A., and Merrill, A.R. 1999. Anal. Biochem. 272, 216.
Legal Information
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
Storage Class
6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
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