This product can be stored at room temperature due to its stability. Optimal temperature information is not available for this product; however, a similar product indicates that the optimal temperature is 60 °C.
R6148
RNase A solution
Synonym(s):
GenElute™ RNAse A
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 25 mL | Available to ship TODAYfromMILWAUKEE | $282.00 |
About This Item
NACRES:
NA.52
UNSPSC Code:
12352204
Specific activity:
1500 units/mL, 3000 units/mL
Biological source:
bovine pancreas
Concentration:
20 mg/mL in Tris buffer
biological source
bovine pancreas
Quality Level
form
liquid
specific activity
1500 units/mL, 3000 units/mL
concentration
20 mg/mL in Tris buffer
technique(s)
DNA purification: suitable
storage temp.
room temp
Gene Information
bovine ... RNASE1(282340), RNASE1(280930)
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1 of 1
This Item | |||
|---|---|---|---|
| specific activity 1500 units/mL, 3000 units/mL | specific activity ≥30 units/mg protein | specific activity ≥30 U/mg | specific activity 50-100 Kunitz units/mg protein |
| technique(s) DNA purification: suitable | technique(s) DNA purification: suitable | technique(s) - | technique(s) cell based assay: suitable |
| biological source bovine pancreas | biological source bovine pancreas | biological source bovine pancreas | biological source bovine pancreas |
| Gene Information bovine ... RNASE1(282340), RNASE1(280930) | Gene Information - | Gene Information - | Gene Information - |
| concentration 20 mg/mL in Tris buffer | concentration - | concentration 10 mg/mL | concentration - |
| form liquid | form solution | form solution | form lyophilized powder |
General description
Ribonuclease A (RNase A), a protein composed of three α helices and seven β strands arranged in two "lobes” holds significance as the prototypical domain-swapped protein. It is known for its diverse oligomeric states. The RNase A family derives its name from bovine pancreatic RNase A and is specific to vertebrates. In humans, this family encompasses eight functional members, showcasing its biological relevance.
For sample preparation in GenElute™ kits.
For sample preparation in GenElute™ kits.
Application
Biochem/physiol Actions
Ribonuclease A or bovine pancreatic ribonuclease A (RNase A) enzyme is an endoribonuclease that displays a specific ability to cleave single-stranded RNA on the 3′ side of pyrimidine residues. This endonuclease with 124 amino acids plays a key role in gene duplication, cellular metabolism, and cancer therapy. Its overexpression is closely associated with several types of cancer. Hence, RNase A has the potential to be a promising new biomarker for the diagnosis of malignant tumors and is also used as a specific target for new drug discovery. RNase A is commonly used for the isolation of plasmid DNA.
Preparation Note
For usage requirements, please refer to the kit procedure.
Legal Information
GenElute is a trademark of Sigma-Aldrich Co. LLC
related product
Product No.
Description
Pricing
signalword
Danger
hcodes
pcodes
Hazard Classifications
Resp. Sens. 1
Storage Class
10 - Combustible liquids
flash_point_f
Not applicable
flash_point_c
Not applicable
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Nimesulide inhibits proliferation and induces apoptosis of pancreatic cancer cells by enhancing expression of PTEN
Chu M, et al.
Experimental and Therapeutic Medicine, 16(1), 370-376 (2018)
Homogeneous electrochemiluminescence biosensor for the detection of RNase A activity and its inhibitor
Jiancong N, et al.
Analytical Chemistry, 91, 14751-14756 (2019)
Determination of the presence of 5-methylcytosine in Paramecium tetraurelia
Singh A, et al.
PloS one, 13(10), e0206667-e0206667 (2018)
Protein and Nucleic Acid Folding: Domain Swapping in Proteins
Liu L. and Gronenborn AM
Journal of Separation Science, 3, 148-169 (2012)
MicroRNA-3666 suppresses the growth and migration of glioblastoma cells by targeting KDM2A
Shou T, et al.
Molecular Medicine Reports, 19(2), 1049-1055 (2019)
Global Trade Item Number
| SKU | GTIN |
|---|---|
| R6148-.2ML | 04061837302992 |
| R6148-.6ML | 04061837303029 |
| R6148-1.7ML | 04061837303081 |
| R6148-25ML | 04061836695781 |
| R6148-4ML | 04061837303159 |
| R6148-2ML | 04061837303135 |
| R6148-8ML | 04061837303173 |
| R6148-.1ML | 04061837302954 |
| R6148-2.5ML | 04061837303104 |
| R6148-.25ML | 04061837302978 |
| R6148-1.2ML | 04061837303043 |
| R6148-25ML-CO | 04061837841415 |
| R6148-.4ML | 04061837303012 |
| R6148-1.5ML | 04061837303067 |
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Qual a temperatura ótima da enzima? E qual a temperatura de armazenamento?
1 answer-
Helpful?
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what is the total volume of this product?
1 answer-
The total volume in this item is 25 mL.
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What is the concentration of the RNase a solution in product R6148?
1 answer-
R6148 is solution of 20 mg/ml RNAse A in Tris Buffer with 50% glycerol. A rough estimate of activity is 1000-2000 Kunitz units/ml.
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