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Pomalidomide

Name: Pomalidomide
Brand: SIGMA
Price: 162 USD
Availability: InStock

≥98% (HPLC), powder, HbF inducer

Synonym(s):

1,3-dioxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-amino-N-(2,6-dioxo-3-piperidyl)phthalamide, 4-Amino-2-(2,6-dioxo-3-piperidinyl)-1H-isoindole-1,3(2H)-dione, Actimid, CC-4047, IMiD 3

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Pack Size	SKU	Availability	Price
5 mg		Available to ship TODAYfromMILWAUKEE	$162.00
25 mg		Available to ship TODAYfromMILWAUKEE	$673.00

About This Item

Empirical Formula (Hill Notation):

C₁₃H₁₁N₃O₄

CAS Number:

19171-19-8

Molecular Weight:

273.24

UNSPSC Code:

12352200

PubChem Substance ID:

329819974

NACRES:

NA.77

MDL number:

MFCD12756407

Assay:

≥98% (HPLC)

Form:

powder

Quality level:

100

$162.00

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Product Name

Pomalidomide, ≥98% (HPLC)

ligand

pomalidomide

Quality Level

100

assay

≥98% (HPLC)

form

powder

reaction suitability

reagent type: ligand

color

yellow

solubility

DMSO: ≥14 mg/mL

storage temp.

2-8°C

SMILES string

Nc1cccc2C(=O)N(C3CCC(=O)NC3=O)C(=O)c12

Related Categories

Bioactive Small Molecule Inhibitors

Bioactive Small Molecules

Chemical Biology

Protein Degrader Building Blocks

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Show Differences

1 of 1

This Item	930563	SML2283	930571
Sigma-Aldrich P0018 Pomalidomide	Sigma-Aldrich 930563 Pomalidomide-PEG₂-C₂-azide	Sigma-Aldrich SML2283 Lenalidomide	Sigma-Aldrich 930571 Pomalidomide-piperidine-carboxylic acid
form powder	form powder	form powder	form powder
assay ≥98% (HPLC)	assay ≥95%	assay ≥98% (HPLC)	assay ≥95%
Quality Level 100	Quality Level 100	Quality Level -	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C	storage temp. 2-8°C
solubility DMSO: ≥14 mg/mL	solubility -	solubility DMSO: 2 mg/mL, clear	solubility -
color yellow	color -	color white to beige	color -

Application

Pomalidomide has been used:

to treat BV173 cells to study the role of proteolysis targeting chimera (PROTAC) compound, JQ1-CRBN, in inducing specific class-I major histocompatibility complex (MHC-I) peptides[1]
for apoptosis studies and intracellular calcium analysis[2]
as a fetal hemoglobin (HbF) agent to study the additive effect with UNC0638 on the levels of fetal hemoglobin expression in β-thalassemia/ variant hemoglobin E (HbE) erythroid progenitor cells[3]

Biochem/physiol Actions

Pomalidomide is a second generation immunomodulator, TNF-α inhibitor, and thalidomide analog.

Pomalidomide is an effective fetal hemoglobin (HbF) inducer that downregulates the key &#947-globin repressors, SRY-box transcription factor 6 (SOX6), and BAF chromatin remodeling complex subunit (BCL11A).[3]

Features and Benefits

This compound is featured on the Cytokine Receptors (Tumor Necrosis Receptor Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

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Pomalidomide-PEG₃-NH₂ hydrochloride, ≥95%

901496

Pomalidomide-C₆-CO₂H, ≥98%

901500

Pomalidomide-C₃-CO₂H, ≥95%

901504

Pomalidomide-PEG₃-CO₂H, ≥95%

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Pomalidomide-PEG₁-NH₂hydrochloride, ≥95%

901513

Pomalidomide-PEG₂-NH₂ hydrochloride, ≥95%

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Pomalidomide-PEG₁-Alkyne, ≥98%

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Pomalidomide-PEG₃-Alkyne, ≥95%

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Pomalidomide-PEG₂-Alkyne, ≥95%

901527

Pomalidomide-PEG₁-CO₂H, ≥95%

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Pomalidomide-PEG₂-CO₂H, 95%

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Pomalidomide-C₉-CO₂H, ≥95%

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Lenalidomide, ≥95%

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Pomalidomide-PEG₆-Alkyne

901834

Pomalidomide-PEG₅-Alkyne, ≥95%

901833

Pomalidomide-PEG₄-Alkyne

901830

Pomalidomide-PEG₄-NH₂ hydrochloride, ≥95%

901829

Pomalidomide-PEG₆-CO₂H

901828

Pomalidomide-PEG₅-CO₂H, ≥95%

901824

Pomalidomide-PEG₄-CO₂H

901860

(S,R,S)-AHPC-PEG₆-NH₂ hydrochloride, ≥95%

903434

Pomalidomide-PEG₆-butyl azide, ≥95%

903442

Pomalidomide-PEG₆-butyl iodide, ≥95%

903833

Pomalidomide-PEG2-azide

903825

Pomalidomide-PEG1-azide

903957

(S,R,S)-AHPC-PEG1-azide

904651

(S,R,S)-AHPC-PEG₃-azide, ≥95%

904724

Pomalidomide-PEG₂-butyl iodide, ≥95%

904708

Pomalidomide-C₆-PEG₃-butyl iodide, ≥95%

904678

Pomalidomide-PEG3-azide

904686

Pomalidomide-C₆-PEG₃-butyl azide, ≥95%

904813

(S,R,S)-AHPC-PEG2-azide

904821

(S,R,S)-AHPC-C₆-PEG₃-butyl azide, ≥95%

904880

Pomalidomide-C₆-PEG₁-C₃-PEG₁-butyl azide, ≥95%

904872

Pomalidomide-PEG₂-butyl azide, ≥95%

904864

(S,R,S)-AHPC-PEG₆-butyl azide, ≥95%

905224

Pomalidomide-PEG₆-butyl amine hydrochloride, ≥95%

913979

Biotin-Thalidomide, ≥95%

919381

CCW16, ≥95%

924202

5-Amino-Thalidomide, ≥95%

pictograms

GHS08

signalword

Danger

hcodes

H360D

pcodes

P201 - P202 - P280 - P308 + P313 - P405 - P501

Hazard Classifications

Repr. 1B

Storage Class

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

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Certificates of Analysis (COA)

Lot/Batch Number

0000517956

0000445339

0000430870

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Emma C Fink et al.

Blood, 132(14), 1535-1544 (2018-08-02)

Thalidomide and its derivatives, lenalidomide and pomalidomide, are clinically effective treatments for multiple myeloma and myelodysplastic syndrome with del(5q). These molecules lack activity in murine models, limiting investigation of their therapeutic activity or toxicity in vivo. Here, we report the

S-3-Amino-phthalimido-glutarimide inhibits angiogenesis and growth of B-cell neoplasias in mice.

Suzanne Lentzsch et al.

Cancer research, 62(8), 2300-2305 (2002-04-17)

Thalidomide has recently been shown to be useful in the treatment of multiple myeloma and may also be useful in the treatment of other hematological malignancies. We have identified a new derivative of thalidomide, S-3-[3-amino-phthalimido]-glutarimide (S-3APG) with dual activity against

Synergistic Antimyeloma Activity of Dendritic Cells and Pomalidomide in a Murine Myeloma Model.

Manh-Cuong Vo et al.

Frontiers in immunology, 9, 1798-1798 (2018-08-21)

We have previously shown that immunization with tumor antigen-loaded dendritic cells (DCs) and the immunomodulating drug, lenalidomide, synergistically potentiates the enhancing antitumor immunity in a myeloma mouse model. In this study, we investigated the immunogenicity of DCs combined with pomalidomide

Dynamic control of proinflammatory cytokines Il-1β and Tnf-α by macrophages in zebrafish spinal cord regeneration.

Themistoklis M Tsarouchas et al.

Nature communications, 9(1), 4670-4670 (2018-11-09)

Spinal cord injury leads to a massive response of innate immune cells in non-regenerating mammals, but also in successfully regenerating zebrafish. However, the role of the immune response in successful regeneration is poorly defined. Here we show that inhibiting inflammation

Pomalidomide Ameliorates H₂O₂-Induced Oxidative Stress Injury and Cell Death in Rat Primary Cortical Neuronal Cultures by Inducing Anti-Oxidative and Anti-Apoptosis Effects.

Yan-Rou Tsai et al.

International journal of molecular sciences, 19(10) (2018-10-24)

Due to its high oxygen demand and abundance of peroxidation-susceptible lipid cells, the brain is particularly vulnerable to oxidative stress. Induced by a redox state imbalance involving either excessive generation of reactive oxygen species (ROS) or dysfunction of the antioxidant

View All Related Papers

Global Trade Item Number

SKU	GTIN
P0018-5MG	04061834261841
P0018-25MG	04061833213193

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