Each vial contains approximately 2.5 mg protein. The minimum protein concentration is 2.5 mg/mL. A survey of recent lots indicates a consistent concentration of 5.0 mg/mL. The minimum activity of this enzyme is 1 unit per milligram and varies considerably from lot to lot. This value is reported in the product Certificate of Analysis. Please see the link below to review a sample or lot-specific Certificate:
https://www.sigmaaldrich.com/product/sigma/m7441#product-documentation
M7441
Monoamine Oxidase B human
recombinant, expressed in baculovirus infected BTI insect cells
Sinónimos:
MAO-B
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1 VIAL
US$ 736,00
5 X 1 VIAL
US$ 2.460,00
US$ 736,00
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Permítanos ayudarleNombre del producto
Monoamine Oxidase B human, recombinant, expressed in baculovirus infected BTI insect cells
recombinant
expressed in baculovirus infected BTI insect cells
form
liquid
enzyme activity
≥1 U/mg
packaging
vial of ~2.5 mg
UniProt accession no.
shipped in
dry ice
storage temp.
−70°C
Quality Level
Gene Information
human ... MAOB(4129)
1 of 4
Este artículo | SAB5700997 | M7316 | SRP0517 |
|---|---|---|---|
| Gene Information human ... MAOB(4129) | Gene Information human ... MAOB(4129) | Gene Information human ... MAOA(4128) | Gene Information human ... MAOA(4128) |
| form liquid | form liquid | form liquid | form frozen liquid |
| recombinant expressed in baculovirus infected BTI insect cells | recombinant - | recombinant expressed in baculovirus infected BTI insect cells | recombinant expressed in baculovirus infected Sf9 cells |
| UniProt accession no. | UniProt accession no. | UniProt accession no. | UniProt accession no. |
| storage temp. −70°C | storage temp. −20°C | storage temp. −70°C | storage temp. −70°C |
| shipped in dry ice | shipped in wet ice | shipped in dry ice | shipped in dry ice |
Application
Drugs that inhibit monoamine oxidase B activity are used for the treatment of various neurological disorders including depression. [1]
Biochem/physiol Actions
MAO′s are proteins of the mitochondrial membrane. These enzymes are responsible for catalyzing oxidative deamination of endo- and xenobiotic amines. Substrate specificity differs for each isozyme.
General description
Monoamine Oxidase B is a mitochondrial outermembrane flavoenzyme that is a target for antidepressant and neuroprotective drugs. [4]
Other Notes
kynuramine deamination activity: One unit will deaminate 1 nanomole of kynuramine per minute at pH 7.4 at 37 deg C.
related product
Referencia del producto
Descripción
Precios
Clase de almacenamiento
12 - Non Combustible Liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Dorota Łażewska et al.
Molecules (Basel, Switzerland), 26(12) (2021-07-03)
Neurodegenerative diseases, e.g., Alzheimer's disease (AD), are a key health problem in the aging population. The lack of effective therapy and diagnostics does not help to improve this situation. It is thought that ligands influencing multiple but interconnected targets can
K N Westlund et al.
Neuroscience, 25(2), 439-456 (1988-05-01)
Monoclonal antibodies, specific for either monoamine oxidases A or B, were used to determine the localization of monoamine oxidase in the human brain. Two distinct populations of neurons were detected by immunocytochemical staining. Neurons in regions rich in catecholamines were
The effect of age on the activity and molecular properties of human brain monoamine oxidase
Fowler, C., et al.
Journal of Neural Transmission. General Section, 49, 1-20 (1980)
Aiko Ishiki et al.
Acta neuropathologica communications, 6(1), 53-53 (2018-07-01)
Recent positron emission tomography (PET) studies have demonstrated the accumulation of tau PET tracer in the affected region of progressive supranuclear palsy (PSP) cases. To confirm the binding target of radiotracer in PSP, we performed an imaging-pathology correlation study in
Structure of human monoamine oxidase B, a drug target for the treatment of neurological disorders
Binda, C., et al.
Nature Structural Biology, 9, 22-26 (2001)
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