HPA039836
Anti-RIN3 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-Flj22439, Anti-Ras and rab interactor 3
Sign Into View Organizational & Contract Pricing
Select a Size
100 μL
$598.00
$598.00
Usually ships in 1 week. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)
All Photos(2)
Select a Size
Change View
100 μL
$598.00
About This Item
$598.00
Usually ships in 1 week. (Orders outside of US and Europe, please allow an additional 1-2 weeks for delivery)
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunohistochemistry: 1:200- 1:500
immunogen sequence
AKKNLPTAPPRRRVSERVSLEDQSPGMAAEGDQLSLPPQGTSDGPEDTPRESTEQGQDTEVKASDPHSMPELPRTAKQPPVPPPRKKRISRQLASTLPA
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... RIN3(79890)
General description
Ras and Rab interactor 3 (RIN3) is a novel Rab5-binding protein, encoded by the gene mapped to human chromosome 14q32. The encoded protein belongs to the RIN family of RAS effectors. RIN3 contains a SH2 domain, proline-rich domain, RH domain, vacuolar protein sorting-associated protein (Vps9) domain and ras-associating (RA) domain in the N- terminal region. RIN3 show tissue-specific expression and is highly expressed in mast cells.
Immunogen
Ras and Rab interactor 3 recombinant protein epitope signature tag (PrEST)
Application
Anti-RIN3 antibody produced in rabbit has been used in immunohistochemistry.[1]
Applications in which this antibody has been used successfully, and the associated peer-reviewed papers, are given below.
Immunohistochemistry (1 paper)
Immunohistochemistry (1 paper)
Biochem/physiol Actions
Ras and Rab interactor 3 (RIN3) plays an essential role in vesicular trafficking by interacting with small GTPases such as Ras and Rab14. In addition, it also interacts with amphiphysin II and promotes receptor-mediated endocytosis. Mutations in the gene increases the risk of susceptibility to Paget′s disease of bone (PDB). The encoded protein acts as a guanine nucleotide exchange factor (GEF) for Rab 5 and Rab31. RIN3 plays an important role in basic mast cell functions and pathologies such as mast cell mediated chronic inflammation and mast cell hyperproliferation by regulating receptor tyrosine kinase (KIT) activity.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST79570
Physical form
Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Not finding the right product?
Try our Product Selector Tool.
Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
Choose from one of the most recent versions:
Certificates of Analysis (COA)
Lot/Batch Number
Don't see the Right Version?
If you require a particular version, you can look up a specific certificate by the Lot or Batch number.
Already Own This Product?
Find documentation for the products that you have recently purchased in the Document Library.
Characterization of RIN3 as a guanine nucleotide exchange factor for the Rab5 subfamily GTPase Rab31.
Kajiho H
The Journal of Biological Chemistry, 286(27), 24364-24373 (2011)
RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway.
Kajiho H
Journal of Cell Science, 116(Pt 20), 4159-4168 (2003)
Mahéva Vallet et al.
Human molecular genetics, 24(11), 3286-3295 (2015-02-24)
Paget's disease of bone (PDB) is a common disorder with a strong genetic component characterized by increased but disorganized bone remodelling. Previous genome-wide association studies identified a locus on chromosome 14q32 tagged by rs10498635 which was significantly associated with susceptibility
Genome-wide association identifies three new susceptibility loci for Paget's disease of bone.
Albagha OM
Nature Genetics, 43(7), 685-689 (2011)
RIN3 is a negative regulator of mast cell responses to SCF.
Janson C
PLoS ONE, 7(11), e49615-e49615 (2012)
Active Filters
Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.
Contact Technical Service
