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Glycine hydrochloride

Name: Glycine hydrochloride
Brand: SIGMA

≥99% (HPLC), NMDA receptors regulator, powder

Synonym(s):

Aminoacetic acid hydrochloride, Glycine HCl, Glycocoll hydrochloride, Aminoacetic acid, Aminoethanoic acid, Glycocoll

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About This Item

Linear Formula:

H₂NCH₂CO₂H · HCl

CAS Number:

6000-43-7

Molecular Weight:

111.53

UNSPSC Code:

12352209

eCl@ss:

32160406

PubChem Substance ID:

24895108

NACRES:

NA.32

EC Number:

227-841-8

MDL number:

MFCD00012872

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Product Name

Glycine hydrochloride, ≥99% (HPLC)

Quality Level

300

assay

≥99% (HPLC)

form

powder

mol wt

111.53

storage condition

(Tightly closed Dry)

concentration

≤100%

technique(s)

immunohistochemistry: suitable

mp

176-180 °C (lit.)

solubility

water: 0.5 g/mL, clear, colorless

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Show Differences

1 of 1

This Item	33226	G7126	15527
Sigma-Aldrich G2879 Glycine hydrochloride	Sigma-Aldrich 33226 Glycine	Sigma-Aldrich G7126 Glycine	Sigma-Aldrich 15527 Glycine
technique(s) immunohistochemistry: suitable	technique(s) IR spectroscopy: suitable	technique(s) western blot: suitable	technique(s) IR spectroscopy: suitable
assay ≥99% (HPLC)	assay 99.7-101% (calc. to the dried substance)	assay ≥99% (HPLC)	assay 99-101% (based on anhydrous substance)
Quality Level 300	Quality Level 200	Quality Level 200	Quality Level 200
form powder	form crystalline powder	form powder	form crystalline powder
storage condition (Tightly closed Dry)	storage condition -	storage condition -	storage condition -
mol wt 111.53	mol wt -	mol wt -	mol wt -

General description

Research area: Neuroscience

Application

Glycine hydrochloride has been used as a component of Ag (silver)-stripping buffer for multiplex immunohistochemistry in mice tissues.[1]

Glycine hydrochloride has been used:

in the preparation of glycine-HCl buffer
to elute serum immunoglobulins (IgGs) from the beads in order to check for the complete enrichment of core- and site-specific antibodies
to regenerate the sensor to elute the bound C-reactive protein (CRP)

Biochem/physiol Actions

Glycine acts on receptors which bring out an enhanced chloride conductance. It shows highest concentrations in the spinal cord as compared to elsewhere in the brain. However, it interacts with and allostericaly activates the excitatory receptor N-methyl-D-aspartate (NMDA), thus, resulting in excitatory transmission in brain.[2][3]

Inhibitory neurotransmitter in spinal cord, allosteric regulator of NMDA receptors.

Glycine comprises a single carbon molecule, that is attached to the amino and a carboxyl group. Glycine hydrochloride (Gly·HCl) is capable of liquifying native chitosan and also helps in the preparation of regenerated chitosan membrane. It can serve as an osmoprotectant. Glycine can act as a flexible link in proteins and can also allow the formation of helices. Free glycine may have a protecting role in tissues against ischemia, hypoxia, and reperfusion.Glycine has been studied as a potential treatment for sepsis, arthritis, adult respiratory distress syndrome, and other inflammatory diseases.[4]

related product

Product No.

Description

Pricing

299294

Glycine-¹⁵N, 98 atom % ¹⁵N

pictograms

GHS05

signalword

Danger

hcodes

H314

pcodes

P260 - P280 - P303 + P361 + P353 - P304 + P340 + P310 - P305 + P351 + P338 - P363

Hazard Classifications

Eye Dam. 1 - Skin Corr. 1

Storage Class

8A - Combustible corrosive hazardous materials

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Hydrolysis of organic phosphates by commercially available phytases: Biocatalytic potentials and effects of ions on their enzymatic activities

Tazisong IA, et al.

Journal of food, agriculture & environment, 6(3&4), 500-505 (2008)

A comparative study on the chitosan membranes prepared from glycine hydrochloride and acetic acid

Ma B, et al.

Carbohydrate Polymers, 91(2), 477-482 (2013)

Coupling of HIV-1 gp120-derived Core Protein to Paramagnetic Beads and Adsorption Assays

Ingale J and Wyatt RT

Bio-protocol, 5(20) (2015)

Glycine: a new anti-inflammatory immunonutrient.

M D Wheeler et al.

Cellular and molecular life sciences : CMLS, 56(9-10), 843-856 (2001-02-24)

The mechanism of the immunosuppressive effects of glycine and its pathophysiological applications are discussed in this review. Glycine has been well characterized in spinal cord as an inhibitory neurotransmitter which activates a glycine-gated chloride channel (GlyR) expressed in postsynaptic membranes.

Multispectral Imaging of T and B Cells in Murine Spleen and Tumor.

Zipei Feng et al.

Journal of immunology (Baltimore, Md. : 1950), 196(9), 3943-3950 (2016-03-20)

Recent advances in multiplex immunohistochemistry techniques allow for quantitative, spatial identification of multiple immune parameters for enhanced diagnostic and prognostic insight. However, applying such techniques to murine fixed tissues, particularly sensitive epitopes, such as CD4, CD8α, and CD19, has been

View All Related Papers

Protocols

Stripping and Reprobing Western Blotting Membranes

This page shows and discusses three protocols for stripping and reprobing a western blot membrane.

Global Trade Item Number

SKU	GTIN
G2879-1KG	04061826744826
G2879-100G	04061833629543
G2879-500G	04061833629550

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