G1401

Glial Cell Line-derived Neurotrophic Factor from rat

Name: Glial Cell Line-derived Neurotrophic Factor from rat
Brand: SIGMA
Price: 245 USD
Availability: InStock

recombinant, expressed in baculovirus infected Sf21 cells, lyophilized powder, suitable for cell culture, ≥97% (SDS-PAGE)

Synonym(s):

ATF, Astrocyte-derived trophic factor, GDNF

Slide 1 of 1

Select a Size

10 μG

$245.00

Estimated to ship onApril 17, 2026Details

About This Item

MDL number:

MFCD01093875

NACRES:

NA.32

UNSPSC Code:

12352202

Key Documents

View All Documentation

biological source

rat

Quality Level

200

recombinant

expressed in baculovirus infected Sf21 cells

assay

≥97% (SDS-PAGE)

form

lyophilized powder

potency

0.10-10 ng/mL

mol wt

~30 kDa

packaging

pkg of 10 μg

storage condition

avoid repeated freeze/thaw cycles

technique(s)

cell culture | mammalian: suitable

impurities

endotoxin, tested

UniProt accession no.

Q07731

storage temp.

−20°C

Gene Information

rat ... Gdnf(25453)

Related Categories

Cell Culture & Analysis

Cell Culture Supplements & Reagents

Growth Factors and Cytokines

Molecular Biology & Functional Genomics

Compare Similar Items

View Full Comparison

Show Differences

1 of 4

This Item	G1777	P5739	H1404
Sigma-Aldrich G1401 Glial Cell Line-derived Neurotrophic Factor from rat	Sigma-Aldrich G1777 Glial Cell Line-derived Neurotrophic Factor human	Sigma-Aldrich P5739 Placenta Growth Factor-2 from mouse	Sigma-Aldrich H1404 Hepatocyte Growth Factor human
recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in E. coli	recombinant expressed in baculovirus infected Sf21 cells	recombinant expressed in Baculovirus infected High-5 cells
assay ≥97% (SDS-PAGE)	assay ≥98% (SDS-PAGE)	assay >97% (SDS-PAGE)	assay >95% (SDS-PAGE)
technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable
biological source rat	biological source human	biological source mouse	biological source human
Quality Level 200	Quality Level 200	Quality Level 200	Quality Level 200
form lyophilized powder	form lyophilized powder	form lyophilized powder	form lyophilized powder

Biochem/physiol Actions

Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that is a member of the TGF-β superfamily.

Glial cell-derived neurotrophic factor (GDNF) is a neurotrophic factor that is a member of the TGF-β superfamily. GDNF is founding member of the GDNF family of ligands, which to date include GDNF, neurturin (NTN), persephin (PSP) and artemin (ART). GDNF is a glycosylated disulfide-linked homodimeric protein of ~15 kDa. Mature rat and human GDNF share 93% sequence homology with strong species cross-reactivity. GDNF promotes survival of various neuronal cells in central and peripheral nervous systems and different stages of development including motoneurons, midbrain dopaminergic neurons, Purkinje cells, and sympathetic neurons. Cells known to express GDNF include Sertoli cells, type 1 astrocytes, Schwann cells, neurons, pinealocytes, and skeletal muscle cells. In addition, exogenously applied GDNF has been shown to rescue damaged facial motor neurons in vivo.

Physical form

Lyophilized from 50 μL of a 0.2 um filtered solution in PBS, pH 7.4 with 50 ug BSA per 1 ug as a carrier protein

Analysis Note

The biological activity of GDNF is measured by its ability to bind to immobilized rrGFRa1/Fc in a functional ELISA.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Alginate-matrigel microencapsulated schwann cells for inducible secretion of glial cell line derived neurotrophic factor.

Roche C de Guzman et al.

Journal of microencapsulation, 25(7), 487-498 (2009-02-25)

Controlled expression of glial cell line derived neurotrophic factor (Gdnf) can be integrated in the development of a system for repair of injured peripheral nerves. This delivery strategy was demonstrated via inducible Gdnf from microencapsulated cells in barium alginate. The

Protocol for dissection and culture of murine dorsal root ganglia neurons to study neuropeptide release.

Caroline Perner et al.

STAR protocols, 2(1), 100333-100333 (2021-02-23)

In this protocol, we provide step-by-step instructions for dissection and culture of primary murine dorsal root ganglia (DRG), which provide an opportunity to study the functional properties of peripheral sensory neurons in vitro. Further, we describe the analysis of neuropeptide

GDNF is involved in the barrier-inducing effect of enteric glial cells on intestinal epithelial cells under acute ischemia reperfusion stimulation.

Weidong Xiao et al.

Molecular neurobiology, 50(2), 274-289 (2014-06-01)

Acute intestinal ischemia reperfusion (IR) injury is often associated with intestinal epithelial barrier (IEB) dysfunction. Enteric glial cells (EGCs) play an essential role in maintaining the integrity of IEB functions. However, the precise mechanism of EGCs under IR stimulation remains

Ginkgolides protect against amyloid-beta1-42-mediated synapse damage in vitro.

Clive Bate et al.

Molecular neurodegeneration, 3, 1-1 (2008-01-09)

The early stages of Alzheimer's disease (AD) are closely associated with the production of the Abeta1-42 peptide, loss of synapses and gradual cognitive decline. Since some epidemiological studies showed that EGb 761, an extract from the leaves of the Ginkgo

Nanotechnology versus stem cell engineering: in vitro comparison of neurite inductive potentials.

Michela Morano et al.

International journal of nanomedicine, 9, 5289-5306 (2014-12-09)

Innovative nerve conduits for peripheral nerve reconstruction are needed in order to specifically support peripheral nerve regeneration (PNR) whenever nerve autotransplantation is not an option. Specific support of PNR could be achieved by neurotrophic factor delivery within the nerve conduits

View All Related Papers

Global Trade Item Number

SKU	GTIN
G1401-10UG	04061833628096

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service