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Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse

Name: Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse
Brand: SIGMA
Price: 397 USD
Availability: InStock

clone F4, ascites fluid

Synonym(s):

Anti-EGFR

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Pack Size	SKU	Availability	Price
100 μL		Available to ship TODAYfromMILWAUKEE	$397.00
0.2 mL		Available to ship TODAYfromMILWAUKEE	$618.00

About This Item

UNSPSC Code:

51111800

NACRES:

NA.41

MDL number:

MFCD00162282

Conjugate:

unconjugated

Clone:

F4, monoclonal

Application:

ARR, ELISA (i), IHC (f), IHC (p), IP, WB

Citations:

$397.00

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biological source

mouse

Quality Level

200

conjugate

unconjugated

antibody form

ascites fluid

antibody product type

primary antibodies

clone

F4, monoclonal

contains

15 mM sodium azide

species reactivity

human

packaging

antibody small pack of 25 μL

technique(s)

immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, immunohistochemistry (frozen sections): suitable, immunoprecipitation (IP): suitable, indirect ELISA: suitable, microarray: suitable, western blot: 1:2,000

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Related Categories

Antibodies by Application

Primary Antibodies

Protein Biology

Small Pack Size Antibodies

Antibodies - Primary, Secondary & Recombinant Monoclonal

General description

Monoclonal Anti-Epidermal Growth Factor (EGF) Receptor (mouse IgG1 isotype) is derived from the hybridoma produced by the fusion of mouse myeloma cells and splenocytes from an immunized mouse. The receptor for epidermal growth factor is an integral cell membrane protein of 170 kD, which spans the membranes of a wide range of normal and malignant epithelial cells. EGF-R have been identified in sarcomas, gliomas, breast, bladder, lung and gynecological tumors. The EGF-R has a half-life of approximately 10 hours in human fibroblasts, but in the presence of EGF this value is reduced to about 1 hour.

Immunogen

synthetically produced residues 985-996 of the human EGF receptor.

Application

Monoclonal Anti-Epidermal Growth Factor Receptor antibody produced in mouse has been used in:

western blotting[1]
immunoprecipitation
immunocytochemistry
immunohistochemical staining

Biochem/physiol Actions

EGFR is a transmembrane glycoprotein that binds to the EGF family. It is a pivotal regulator of cell proliferation, growth, differentiation and DNA repair after radiation-induced damage. Mutations in the gene encoding EGFR are associated with a number of malignancies including lung cancer and colorectal cancer.

Epidermal growth factor receptor (EGF-R) is a tyrosine-specific protein kinase with the capacity to phosphorylate tyrosine residues located near its carboxy-terminus.

This antibody recognizes specifically an intracellular domain of the EGF receptor.

Disclaimer

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class

10 - Combustible liquids

wgk

nwg

flash_point_f

Not applicable

flash_point_c

Not applicable

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

0000533016

0000525928

0000527511

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Cetuximab and bevacizumab: preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck.

A Argiris et al.

Annals of oncology : official journal of the European Society for Medical Oncology, 24(1), 220-225 (2012-08-18)

We evaluated combined targeting with cetuximab, an anti-epidermal growth factor receptor (EGFR) monoclonal antibody, and bevacizumab, an anti-vascular endothelial growth factor (VEGF) monoclonal antibody, in squamous cell carcinoma of the head and neck (SCCHN). The combination was studied in human

Preclinical PET imaging of EGFR levels: pairing a targeting with a non-targeting Sel-tagged Affibody-based tracer to estimate the specific uptake.

Qing Cheng et al.

EJNMMI research, 6(1), 58-58 (2016-07-09)

Though overexpression of epidermal growth factor receptor (EGFR) in several forms of cancer is considered to be an important prognostic biomarker related to poor prognosis, clear correlations between biomarker assays and patient management have been difficult to establish. Here, we

Metabolism of epidermal growth factor receptor targeting probe [11C]PD153035: impact on biodistribution and tumor uptake in rats.

Erik Samén et al.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 54(10), 1804-1811 (2013-09-05)

Several tracers have been evaluated as probes for noninvasive epidermal growth factor receptor (EGFR) quantification with PET. One of the most promising candidates is the (11)C-labeled analog of the EGFR tyrosine kinase inhibitor PD153035. However, previous in vitro studies indicated

Changes in expression of epidermal growth factor receptors by anterior pituitary cells during the estrous cycle: cyclic expression by gonadotropes

Armstrong J and Childs GV

Endocrinology, 138(5), 1903-1908 (1997)

Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway

Steen H, et al.

The Journal of Biological Chemistry, 277(2), 1031-1039 (2002)

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Global Trade Item Number

SKU	GTIN
E3138-100UL	04061838030900
E3138-25UL	04061838029461
E3138-.2ML	04061838105080

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