Stability information for A8185 in solution has not been reported. It would be advisable to make the solutions fresh.
If necessary, storage at -20°C in single-use aliquots for approximately one month can be attempted.
A8185
Ala-Gln
BioReagent, suitable for cell culture, suitable for insect cell culture
Synonym(s):
Alanyl-glutamine, Glutamine-S
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5 G
$137.00
100 G
$2,300.00
1 KG
$12,690.00
$137.00
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About This Item
Empirical Formula (Hill Notation):
C8H15N3O4
CAS Number:
Molecular Weight:
217.22
UNSPSC Code:
12352209
PubChem Substance ID:
NACRES:
NA.75
Skip To
product line
BioReagent
Quality Level
assay
≥98% (HPLC)
form
powder
technique(s)
cell culture | insect: suitable, cell culture | mammalian: suitable
color
white to off-white
storage temp.
room temp
SMILES string
NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O
InChI
1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1
InChI key
HJCMDXDYPOUFDY-WHFBIAKZSA-N
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This Item | |||
|---|---|---|---|
| form powder | form powder | form powder | form powder |
| assay ≥98% (HPLC) | assay ≥99.5% (NT) | assay ≥98% (HPLC) | assay ≥98% (HPLC) |
| technique(s) cell culture | insect: suitable, cell culture | mammalian: suitable | technique(s) cell culture | mammalian: suitable | technique(s) - | technique(s) cell culture | insect: suitable, cell culture | mammalian: suitable |
| product line BioReagent | product line BioUltra | product line - | product line BioReagent |
| storage temp. room temp | storage temp. - | storage temp. - | storage temp. - |
| color white to off-white | color white | color white to off-white | color white |
Application
Ala-Gln has been used:
- as a supplement in NeuralQ™ medium
- as a component in growth medium and incubation medium (IM) for retinal cell lines
- for experimental treatment of retinal cell lines respectively
Biochem/physiol Actions
Alanyl-glutamine (Ala-Gln) is a dipeptide that is used as a substitute for glutamine in mammalian cell culture media, because of the instability of glutamine in solution and the formation of ammonia as a breakdown product of glutamine in solution, which can have deleterious effects on cells in culture. Ala-Glu is stable to heat sterilization and is less ammonia genic than glutamine, which contributes to its advantages as a media component. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro.[1]
Analysis Note
This product is cell culture tested (0.5 mg/ml) and insect cell culture tested (0.2 mg/ml). It is appropriate for use in cell culture and insect cell culture applications at 2-10 mM.
Legal Information
NeuralQ is a trademark of GlobalStem
Storage Class
11 - Combustible Solids
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Vinicius Fernandes Cruzat et al.
Nutrition (Burbank, Los Angeles County, Calif.), 25(4), 428-435 (2008-12-06)
We investigated the effect of supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine, both in the free form, on the plasma and tissue concentrations of glutamine, glutamate, and glutathione (GSH) in rats subjected to long-duration
Vinicius Fernandes Cruzat et al.
Cell biochemistry and function, 28(1), 24-30 (2009-11-04)
In this study, we investigated the effect of the supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine on plasma levels markers of muscle damage and levels of pro-inflammatory cytokines and glutamine metabolism in rats submitted
A high-throughput assay for mRNA silencing in primary cortical neurons in vitro with oligonucleotide therapeutics
Alterman JF, et al.
Bio-protocol, 7(16) (2017)
T Hassell et al.
Applied biochemistry and biotechnology, 30(1), 29-41 (1991-07-01)
Eight independent cell lines accumulated ammonia in culture to concentrations between 1.3 and 2.9 mM. The growth inhibition of such concentrations of ammonium chloride when added to culture medium was variable. The cell lines tested could be divided into 3
The adaptation of BHK cells to a non-ammoniagenic glutamate-based culture medium
Christie A, et al.
Biotechnology and Bioengineering, 64(3), 298-309 (1999)
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Product Information Sheet
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A8185-1KG | 04061833391273 |
| A8185-100G | 04061833391266 |
| A8185-5G | 04061835568093 |
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