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Ala-Gln

Name: Ala-Gln
Brand: SIGMA

BioReagent, suitable for cell culture, suitable for insect cell culture

Synonym(s):

Alanyl-glutamine, Glutamine-S

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About This Item

Empirical Formula (Hill Notation):

C₈H₁₅N₃O₄

CAS Number:

39537-23-0

Molecular Weight:

217.22

UNSPSC Code:

12352209

PubChem Substance ID:

24891211

NACRES:

NA.75

Pricing and availability is not currently available.

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product line

BioReagent

Quality Level

300

assay

≥98% (HPLC)

form

powder

technique(s)

cell culture | insect: suitable, cell culture | mammalian: suitable

color

white to off-white

storage temp.

room temp

SMILES string

NC(CC[C@H](NC([C@@H](N)C)=O)C(O)=O)=O

InChI

1S/C8H15N3O4/c1-4(9)7(13)11-5(8(14)15)2-3-6(10)12/h4-5H,2-3,9H2,1H3,(H2,10,12)(H,11,13)(H,14,15)/t4-,5-/m0/s1

InChI key

HJCMDXDYPOUFDY-WHFBIAKZSA-N

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Biochemicals

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Show Differences

1 of 1

This Item	49419	A0550	A4159
Sigma-Aldrich A8185 Ala-Gln	Sigma-Aldrich 49419 L-Glutamine	Sigma-Aldrich A0550 Ala-Gln	Sigma-Aldrich A4159 L-Asparagine
form powder	form powder	form powder	form powder
technique(s) cell culture \| insect: suitable, cell culture \| mammalian: suitable	technique(s) cell culture \| mammalian: suitable	technique(s) -	technique(s) cell culture \| insect: suitable, cell culture \| mammalian: suitable
assay ≥98% (HPLC)	assay ≥99.5% (NT)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
product line BioReagent	product line BioUltra	product line -	product line BioReagent
storage temp. room temp	storage temp. -	storage temp. -	storage temp. -
Quality Level 300	Quality Level 100	Quality Level 200	Quality Level 400

Application

Ala-Gln has been used:

as a supplement in NeuralQ^™ medium
as a component in growth medium and incubation medium (IM) for retinal cell lines
for experimental treatment of retinal cell lines respectively

Biochem/physiol Actions

Alanyl-glutamine (Ala-Gln) is a dipeptide that is used as a substitute for glutamine in mammalian cell culture media, because of the instability of glutamine in solution and the formation of ammonia as a breakdown product of glutamine in solution, which can have deleterious effects on cells in culture. Ala-Glu is stable to heat sterilization and is less ammonia genic than glutamine, which contributes to its advantages as a media component. Ala-Gln has been utilized to investigate polymorphonuclear leucocyte and myeloperoxidase activity in vitro.[1]

Analysis Note

This product is cell culture tested (0.5 mg/ml) and insect cell culture tested (0.2 mg/ml). It is appropriate for use in cell culture and insect cell culture applications at 2-10 mM.

Legal Information

NeuralQ is a trademark of GlobalStem

Storage Class

11 - Combustible Solids

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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A high-throughput assay for mRNA silencing in primary cortical neurons in vitro with oligonucleotide therapeutics

Alterman JF, et al.

Bio-protocol, 7(16) (2017)

Effects of oral supplementation with glutamine and alanyl-glutamine on glutamine, glutamate, and glutathione status in trained rats and subjected to long-duration exercise.

Vinicius Fernandes Cruzat et al.

Nutrition (Burbank, Los Angeles County, Calif.), 25(4), 428-435 (2008-12-06)

We investigated the effect of supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine, both in the free form, on the plasma and tissue concentrations of glutamine, glutamate, and glutathione (GSH) in rats subjected to long-duration

The adaptation of BHK cells to a non-ammoniagenic glutamate-based culture medium

Christie A, et al.

Biotechnology and Bioengineering, 64(3), 298-309 (1999)

Effects of supplementation with free glutamine and the dipeptide alanyl-glutamine on parameters of muscle damage and inflammation in rats submitted to prolonged exercise.

Vinicius Fernandes Cruzat et al.

Cell biochemistry and function, 28(1), 24-30 (2009-11-04)

In this study, we investigated the effect of the supplementation with the dipeptide L-alanyl-L-glutamine (DIP) and a solution containing L-glutamine and L-alanine on plasma levels markers of muscle damage and levels of pro-inflammatory cytokines and glutamine metabolism in rats submitted

L-Glutamine or L-alanyl-L-glutamine prevents oxidant- or endotoxin-induced death of neonatal enterocytes.

Tony E Haynes et al.

Amino acids, 37(1), 131-142 (2009-02-04)

This study tested the hypothesis that L-glutamine (Gln) or L-alanyl-L-glutamine (Ala-Gln) prevents oxidant- or endotoxin-induced death of neonatal enterocytes. Enterocytes of neonatal pigs rapidly hydrolyzed Ala-Gln and utilized Gln. To determine whether Gln or Ala-Gln has a cytoprotective effect, IPEC-1

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Global Trade Item Number

SKU	GTIN
A8185-1KG	04061833391273
A8185-100G	04061833391266
A8185-5G	04061835568093

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