The concentration of this antibody may range from 15 - 55 mg/mL and is reported in the lot specific Certificate of Analysis. Please see the link below to review a sample or lot specific Certificate:
https://www.sigmaaldrich.com/product/sigma/a6684#product-documentation
A6684
Monoclonal Anti-Albumin antibody produced in mouse
clone HSA-11, ascites fluid
Synonym(s):
Anti-AFP
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100 μL
$397.00
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$618.00
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About This Item
Conjugate:
unconjugated
Clone:
HSA-11, monoclonal
Application:
ELISA (i), IHC (p), WB
Citations:
60
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biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
ascites fluid
antibody product type
primary antibodies
clone
HSA-11, monoclonal
contains
15 mM sodium azide
species reactivity
gibbon, baboon, human, rhesus monkey
should not react with
turkey, feline, hamster, pigeon, rat, marmoset, pig, bovine, canine, donkey, guinea pig, rabbit, chicken, sheep, goat
technique(s)
immunohistochemistry (formalin-fixed, paraffin-embedded sections): suitable, indirect ELISA: 1:10,000, western blot: 1:5,000
isotype
IgG2a
UniProt accession no.
shipped in
dry ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... ALB(213)
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1 of 4
This Item | |||
|---|---|---|---|
| species reactivity gibbon, baboon, human, rhesus monkey | species reactivity rhesus monkey, baboon, human | species reactivity human | species reactivity human |
| clone HSA-11, monoclonal | clone HSA-9, monoclonal | clone 1G12-1B3, monoclonal | clone AL-01, monoclonal |
| conjugate unconjugated | conjugate unconjugated | conjugate unconjugated | conjugate unconjugated |
| antibody form ascites fluid | antibody form ascites fluid | antibody form purified immunoglobulin | antibody form purified immunoglobulin |
| Gene Information human ... ALB(213) | Gene Information human ... ALB(213) | Gene Information human ... ALB(213) | Gene Information human ... ALB(213) |
| biological source mouse | biological source mouse | biological source mouse | biological source mouse |
General description
Monoclonal Anti-Albumin (mouse IgG2a isotype) is derived from the HSA-11 hybridoma produced by the fusion of mouse myeloma cells and splenocytes from immunized BALB/c mice. Albumin, the major protein produced by the liver, represents more than half the total protein in human serum. Many other body fluids also contain albumin.
Serum albumin is the major protein component of blood and is produced in the liver. It regulates colloid osmotic blood pressure, transportation of a variety of substances, blood pH and provides an endogenous source of amino acids. Monoclonal anti-albumin antibody (diluted 1:100) can be used in double staining to localize hepatocytes differentiated from human umbilical mesenchymal stem cells (HUMSCs) [1]. Offering specificity for human serum albumin, this product is ideal for identification of human blood stains or other body fluids (e.g., seminal fluid, milk, urine, saliva, vaginal secretions). Mouse monoclonal anti-albumin antibody reacts specifically with denatured and reduced human serum albumin and cross reacts with rhesus, gibbon and baboon serum albumins. The product has shown no cross reactivity with bovine, cat, chicken, dog, donkey, goat, guinea pig, hamster, marmoset, pig, pigeon, rabbit, rat, sheep, or turkey serum albumin or with chicken and turkey egg albumin.
Immunogen
Human serum albumin
Application
Monoclonal Anti-Albumin antibody produced in mouse has been used in:
- immunofluorescence
- staining
- double staining[1]
- enzyme-linked immunosorbent assay (ELISA)
- immunoblot
- immunohistochemistry
Biochem/physiol Actions
Albumin is a transport protein that binds a broad range of ligands such as fatty acids, bilirubin, hemin, drugs, amino acids and ions . Albumin may also function as a zinc carrier protein and consequently regulate physiological processes .
High levels of albumin are associated with dehydration. Albumin turnover is seen in infants with iron deficiency anemia. Oxidative damage of albumin is associated with advanced liver disease.
The antibody is specific for human albumin in serum and plasma and recognizes an epitope resistant to reduction or denaturation.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
13 - Non Combustible Solids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
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Elevated albumin in retinas of monkeys with experimental glaucoma
Carter DL, et al.
Investigative Ophthalmology & Visual Science, 51(2), 952-959 (2010)
Anne Casset et al.
International archives of allergy and immunology, 159(3), 253-262 (2012-06-23)
Diagnosis and immunotherapy of house-dust mite (HDM) allergy is still based on natural allergen extracts. The aim of this study was to analyze commercially available Dermatophagoides pteronyssinus extracts from different manufacturers regarding allergen composition and content and whether variations may
Yoon Ok Jang et al.
BMC gastroenterology, 14, 198-198 (2014-11-27)
Cirrhosis is a long-term consequence of chronic hepatic injury with fibrosis. No effective therapy is currently available for decompensated cirrhosis except liver transplantation. Hence, we investigated the effect of bone marrow-derived mesenchymal stem cells (BM-MSCs) on hepatic fibrosis in a
Obinna C Ubah et al.
Frontiers in immunology, 8, 1780-1780 (2018-01-10)
The management of chronic inflammatory diseases, such as inflammatory bowel disease, psoriasis, and rheumatoid arthritis has significantly improved over the last decade with the clinical availability of anti-TNF-α biologics. Despite this undoubted treatment success, a combination of acquired resistance together
Arnout Schepers et al.
Lab on a chip, 16(14), 2644-2653 (2016-06-15)
In vitro models of human tissue are crucial to our ability to study human disease as well as develop safe and effective drug therapies. Models of single organs in static and microfluidic culture have been established and shown utility for
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Instructions
Global Trade Item Number
| SKU | GTIN |
|---|---|
| A6684-100UL | 04061837856204 |
| A6684-.2ML | 04061833382691 |
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