P9763
L-α-Phosphatidylinositol 4,5-diphosphate sodium salt from bovine brain
≥98% (TLC)
Synonym(s):
1,2-Diacyl-sn-glycero-3-phospho-(1-D-myo-inositol 4,5-bisphosphate) sodium salt, PIP2, Triphosphoinositide sodium salt
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About This Item
UNSPSC Code:
12352211
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biological source
bovine brain
assay
≥98% (TLC)
form
powder
functional group
phospholipid
shipped in
dry ice
storage temp.
−20°C
Biochem/physiol Actions
Formed in brain membranes from PIP by PIP kinase; a component of mechanisms involving receptor-stimulated phospholipase C; stimulates brain phospholipase D in vitro.
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
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Shanjin Huang et al.
Molecular biology of the cell, 17(4), 1946-1958 (2006-01-27)
The cytoskeleton is a key regulator of morphogenesis, sexual reproduction, and cellular responses to extracellular stimuli. Changes in the cellular architecture are often assumed to require actin-binding proteins as stimulus-response modulators, because many of these proteins are regulated directly by
Euripedes de Almeida Ribeiro et al.
Cell, 159(6), 1447-1460 (2014-12-01)
The spectrin superfamily of proteins plays key roles in assembling the actin cytoskeleton in various cell types, crosslinks actin filaments, and acts as scaffolds for the assembly of large protein complexes involved in structural integrity and mechanosensation, as well as
Sophie Lev et al.
Infection and immunity, 81(4), 1245-1255 (2013-02-06)
Phospholipase C (PLC) of Cryptococcus neoformans (CnPlc1) is crucial for virulence of this fungal pathogen. To investigate the mechanism of CnPlc1-mediated signaling, we established that phosphatidylinositol 4,5-bisphosphate (PIP(2)) is a major CnPlc1 substrate, which is hydrolyzed to produce inositol trisphosphate
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