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L7757

Lidocaine

≥98% (GC), powder, neuroprotective agent

Synonym(s):

2-Diethylamino-N-(2,6-dimethylphenyl)acetamide, Lignocaine, Xylocaine

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25 G

$62.00

100 G

$209.00

$62.00

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About This Item

Empirical Formula (Hill Notation):
C14H22N2O
CAS Number:
137-58-6
Molecular Weight:
234.34
NACRES:
NA.77
PubChem Substance ID:
24896480
UNSPSC Code:
12352200
EC Number:
205-302-8
MDL number:
MFCD00026733
Form:
powder
Quality level:
100

Key Documents

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Product Name

Lidocaine, powder

form

powder

Quality Level

100

SMILES string

CCN(CC)CC(=O)Nc1c(C)cccc1C

InChI

1S/C14H22N2O/c1-5-16(6-2)10-13(17)15-14-11(3)8-7-9-12(14)4/h7-9H,5-6,10H2,1-4H3,(H,15,17)

InChI key

NNJVILVZKWQKPM-UHFFFAOYSA-N

Gene Information

human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1a(25122)

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1 of 4

This Item
L10261366002BP727
Lidocaine powder

Sigma-Aldrich

L7757

Lidocaine

Lidocaine analytical standard

Sigma-Aldrich

L1026

Lidocaine

Lidocaine United States Pharmacopeia (USP) Reference Standard

USP

1366002

Lidocaine

Lidocaine British Pharmacopoeia (BP) Reference Standard

BP727

Lidocaine

form

powder

form

solid

form

-

form

solid

Quality Level

100

Quality Level

200

Quality Level

-

Quality Level

-

Gene Information

human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1a(25122)

Gene Information

human ... CYP1A2(1544), SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)
rat ... Scnn1a(25122)

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

Gene Information

human ... SCN10A(6336), SCN11A(11280), SCN1A(6323), SCN2A(6326), SCN3A(6328), SCN4A(6329), SCN5A(6331), SCN7A(6332), SCN8A(6334), SCN9A(6335)

General description

Lidocaine is a local anesthetic and an effective antiarrhythmia agent. It occurs as solutions of crystalline colorless solid for injections, that has a short half-life within plasma.

Application

Lidocaine may be used for drug testing and for voltage clamp experiments.

Biochem/physiol Actions

Na+ channel blocker; class IB antiarrhythmic that is rapidly absorbed after parenteral administration.
Na+ channel blocker; class IB antiarrhythmic.
Lidocaine, a neuroprotective agent, mediates blockage of sodium (Na+) channels. It prevents the influx of sodium ions leading to depolarization of sodium channels and metabolically inactivated in liver. Lidocaine has positive effect on cerebral ischemia. It is also used in the treatment of ventricular tachycardia. Lidocaine is an efficient anesthetic agent in ophthalmic surgeries as it is highly potent and has good tissue penetrability.

pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

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Certificates of Analysis (COA)

Lot/Batch Number
MKCX8926
0000286319
0000286319
MKCV1175
MKCS8025

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Pharmacokinetics and pharmacodynamics of lignocaine: a review
Weinberg L, et al.
World Journal of Anesthesiology, 4(2), 17-29 (2015)
Mitochondrial injury and caspase activation by the local anesthetic lidocaine
Johnson ME, et al.
Anesthesiology, 101(5), 1184-1194 (2004)
Principles of Pharmacology: The Pathophysiologic Basis of Drug Therapy (2008)
Cytotoxicity of lidocaine to human corneal endothelial cells in vitro
Yu HZ, et al.
Basic and Clinical Pharmacology and Toxicology, 114(4), 352-359 (2014)
Neuroprotective effect of low-dose lidocaine in a rat model of transient focal cerebral ischemia
Lei B, et al.
Anesthesiology, 95(2), 445-451 (2001)
View All Related Papers

Global Trade Item Number

SKUGTIN
L7757-25G04061835374779
L7757-100G04061833965665

Questions

1–4 of 4 Questions  

  1. How does the storage temperature relate to shipping conditions?

    1 answer

    1. The storage conditions that a Sigma-Aldrich catalog and label recommend for products are deliberately conservative. For many products, long-term storage at low temperatures will increase the time during which they are expected to remain in specification and therefore are labeled accordingly. Where short-term storage, shipping time frame, or exposure to conditions other than those recommended for long-term storage will not affect product quality, Sigma-Aldrich will ship at ambient temperature. The products sensitive to short-term exposure to conditions other than their recommended long-term storage are shipped on wet or dry ice. Ambient temperature shipping helps to control shipping costs for our customers. At any time, our customers can request wet- or dry-ice shipment, but the special handling is at customer expense if our product history indicates that the product is stable for regular shipment.

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  2. What is the Department of Transportation shipping information for this product?

    1 answer

    1. Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.

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  3. Is Product L7757, Lidocaine free base, suitable for use as a reference standard?

    1 answer

    1. No. We would recommend Product No. L1026 (Lidocaine, Sigma References Standard). The current lot is current with USP 31, 2nd Supplement, and is traceable to USP Reference Standard lot MOF220.

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  4. How do I dissolve lidocaine free base (Product No. L7757)?

    1 answer

    1. The product is soluble in alcohol, ether, benzene, chloroform and oils, according to the chemicals encyclopedia published by the Royal Society of Chemistry , 14th ed. online  (2006).  Lidocaine hydrochloride monohydrate (Product No. L5647) is soluble in water.  Since the lidocaine hydrochloride is so much more soluble than lidocaine free base, lowering the pH to that of the hydrochloride (pH 4.0-5.5) or to that of injectable forms (pH 5.0-7.0) should greatly enhance the solubility of L7757.

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