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HPA030086

Sigma-Aldrich

Anti-RAB11FIP3 antibody produced in rabbit

Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution

Synonym(s):

Anti-Eferin, Anti-KIAA0665, Anti-RAB11 family interacting protein 3 (class II), Anti-Rab11-FIP3

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About This Item

UNSPSC Code:
12352203
Human Protein Atlas Number:
HPA030086
NACRES:
NA.41

biological source

rabbit

conjugate

unconjugated

antibody form

affinity isolated antibody

antibody product type

primary antibodies

clone

polyclonal

product line

Prestige Antibodies® Powered by Atlas Antibodies

form

buffered aqueous glycerol solution

species reactivity

human

technique(s)

immunohistochemistry: 1:500- 1:1000

immunogen sequence

QVKDLTKYLDPSGLGVISFEDFYQGITAIRNGDPDGQCYGGVASAQDEEPLACPDEFDDFVTYEANEVTDSAYMGSESTYSECETF

UniProt accession no.

O75154

shipped in

wet ice

storage temp.

−20°C

target post-translational modification

unmodified

Gene Information

human ... RAB11FIP3(9727)

Related Categories

General description

RAB11FIP3 (RAB11 family interacting protein 3) is also termed as arfophilin and eferin. It is a Rab11 and ADP-ribosylation factor (ARF) binding protein. The RAB11FIP3 gene is located on human chromosome 16p13.3.

Immunogen

RAB11 family interacting protein 3 (class II) recombinant protein epitope signature tag (PrEST)

Application

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies® protocols and other useful information.

Biochem/physiol Actions

RAB11FIP3 (RAB11 family interacting protein 3) participates in trafficking events like migrating endosomally-derived membranes to the cleavage furrow during cytokinesis. It helps to maintain the structural integrity of the endosomal recycling compartment. RAB11FIP3 modulates cytokinesis.

Features and Benefits

Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:
  • IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
  • Protein array of 364 human recombinant protein fragments.

Linkage

Corresponding Antigen APREST77868

Physical form

Solution in phosphate buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide.

Legal Information

Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class

10 - Combustible liquids

wgk_germany

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Molecular characterization of Rab11-FIP3 binding to ARF GTPases.
Schonteich E, et al.
European Journal of Cell Biology, 86(8), 417-431 (2007)
Rab11?FIP3 is critical for the structural integrity of the endosomal recycling compartment.
Horgan CP, et al.
Traffic, 8(4), 414-430 (2007)
Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis.
Horgan CP, et al.
Biochemical and Biophysical Research Communications, 319(1), 83-94 (2004)
The iron-sulfur cluster assembly network component NARFL is a key element in the cellular defense against oxidative stress.
Corbin MV, et al.
Free Radical Biology & Medicine, 89, 863-872 (2015)

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