Anti-PON3 antibody produced in rabbit

PON3 (paraoxonase 3) belongs to the PON family of enzymes, which consists of three members. This gene is located on human chromosome 7q21-22. It has a wide range of expression. It is produced in liver, and has a molecular weight of ~40kDa.

Serum paraoxonase/lactonase 3 recombinant protein epitope signature tag (PrEST)

All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project and as a result, are supported by the most extensive characterization in the industry.

The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. We also provide Prestige Antibodies^® protocols and other useful information.

PON3 (paraoxonase 3) is responsible for delaying the oxidation of low-density lipoprotein (LDL) and cell oxidative stress. The protein products this enzyme generates, are associated with high-density lipoprotein (HDL), circulating in blood. The exact function of PON3 is not well understood. However, studies show that this enzyme acts like an antioxidant, and hydrolyses oxidized lipid peroxides. It also has lactonase activity. The serum concentrations of this protein are increased in HIV patients, and are related to the oxidative status. PON3 serum concentration is also elevated in atherosclerosis, and this results in decreased insulin sensitivity in peripheral artery disease, and inflammation in coronary artery disease.

Prestige Antibodies^® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies^® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.

Every Prestige Antibody is tested in the following ways:

• IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
• Protein array of 364 human recombinant protein fragments.

Corresponding Antigen APREST71744

Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide

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