HPA000939
Anti-MOAP1 antibody produced in rabbit
Prestige Antibodies® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution
Synonym(s):
Anti-MAP-1 antibody produced in rabbit, Anti-MAP1 antibody produced in rabbit, Anti-Modulator of apoptosis 1 antibody produced in rabbit, Anti-Paraneoplastic antigen Ma4 antibody produced in rabbit
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All Photos(2)
About This Item
UNSPSC Code:
12352203
Human Protein Atlas Number:
biological source
rabbit
conjugate
unconjugated
antibody form
affinity isolated antibody
antibody product type
primary antibodies
clone
polyclonal
product line
Prestige Antibodies® Powered by Atlas Antibodies
form
buffered aqueous glycerol solution
species reactivity
human
technique(s)
immunofluorescence: 1-4 μg/mL
immunohistochemistry: 1:50- 1:200
immunogen sequence
RRRLLESLRGPALDVIRVLKINNPLITVDECLQALEEVFGVTDNPRELQVKYLTTYQKDEEKLSAYVLRLEPLLQKLVQRGAIERDAVNQARLDQVIAGAVHKTIRRELNLPEDGPAPGFLQLLVLIKDYEAAE
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
target post-translational modification
unmodified
Gene Information
human ... MOAP1(64112)
General description
Modulator of apoptosis 1 (MOAP-1) is a mitochondria-enriched 39.5kDa protein that has 351 amino acid residues in humans. It is ubiquitously expressed and its expression is observed to be reduced in cancer cell lines. The protein contains a Bcl-2 homology 3 (BH3)-like motif that facilitates its association with Bax protein during mitochondrial-dependent apoptosis. The gene is mapped to human chromosome 14q32.
Immunogen
Modulator of apoptosis 1 recombinant protein epitope signature tag (PrEST)
Application
Anti-MOAP1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project . Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these protocols and other useful information about Prestige Antibodies and the HPA, visit sigma.com/prestige.
Biochem/physiol Actions
Modulator of apoptosis 1 is a protein encoded by the MOAP1 gene in humans. It helps RASSF1A, a tumor suppressor protein, during death receptor-dependent apoptosis. Association of RASSF1A and MOAP1 with death receptors involves an ordered recruitment to receptor complexes to promote cell death and inhibit tumor formation. The gene may act as an effector for promoting Bax function in mitochondria. It is rapidly up-regulated by multiple apoptotic stimuli in mammalian cells. The protein is short-lived and is constitutively degraded by the ubiquitin-proteasome system.
Features and Benefits
Prestige Antibodies® are highly characterized and extensively validated antibodies with the added benefit of all available characterization data for each target being accessible via the Human Protein Atlas portal linked just below the product name at the top of this page. The uniqueness and low cross-reactivity of the Prestige Antibodies® to other proteins are due to a thorough selection of antigen regions, affinity purification, and stringent selection. Prestige antigen controls are available for every corresponding Prestige Antibody and can be found in the linkage section.
Every Prestige Antibody is tested in the following ways:
Every Prestige Antibody is tested in the following ways:
- IHC tissue array of 44 normal human tissues and 20 of the most common cancer type tissues.
- Protein array of 364 human recombinant protein fragments.
Linkage
Corresponding Antigen APREST70374
Physical form
Solution in phosphate-buffered saline, pH 7.2, containing 40% glycerol and 0.02% sodium azide
Legal Information
Prestige Antibodies is a registered trademark of Merck KGaA, Darmstadt, Germany
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Storage Class
10 - Combustible liquids
wgk_germany
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Jennifer Law et al.
Molecular biology international, 2012, 536802-536802 (2012-06-30)
Modulator of apoptosis 1 (MOAP-1) is a BH3-like protein that plays key roles in both the intrinsic and extrinsic modes of cell death or apoptosis. MOAP-1 is part of the Ras association domain family 1A (RASSF1A)/MOAP-1 pro-apoptotic extrinsic signaling pathway
Caitlin J Foley et al.
Molecular and cellular biology, 28(14), 4520-4535 (2008-05-14)
RASSF1A is a tumor suppressor protein involved in death receptor-dependent apoptosis utilizing the Bax-interacting protein MOAP-1 (previously referred to as MAP-1). However, the dynamics of death receptor recruitment of RASSF1A and MOAP-1 are still not understood. We have now detailed
Chong Teik Tan et al.
EMBO reports, 22(1), e50854-e50854 (2021-01-05)
Nrf2 signaling is vital for protecting cells against oxidative stress. However, its hyperactivation is frequently found in liver cancer through excessive build-up of p62/SQSTM1 bodies that sequester Keap1, an adaptor of the E3-ubiquitin ligase complex for Nrf2. Here, we report
Nai Yang Fu et al.
Proceedings of the National Academy of Sciences of the United States of America, 104(24), 10051-10056 (2007-05-31)
The multidomain proapoptotic protein Bax of the Bcl-2 family is a central regulator for controlling the release of apoptogenic factors from mitochondria. Recent evidence suggests that the Bax-associating protein MOAP-1 may act as an effector for promoting Bax function in
K Matsuura et al.
Oncogene, 36(12), 1698-1706 (2016-10-11)
Evasion of apoptosis allows many cancers to resist chemotherapy. Apoptosis is mediated by the serial activation of caspase family proteins. These proteases are often activated upon the release of cytochrome c from the mitochondria, which is promoted by the proapoptotic
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