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Merck

G1660

Galanthamine hydrobromide

From plant (Ungeria victoris), ≥94% (HPLC), Cholinesterase inhibitor, powder

Sinonimo/i:

Galantamine hydrobromide

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2 MG

CHF 80.30

10 MG

CHF 210.00

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Informazioni su questo articolo

Formula empirica (notazione di Hill):
C17H21NO3 · HBr
Numero CAS:
1953-04-4
Peso molecolare:
368.27
UNSPSC Code:
12352116
PubChem Substance ID:
24895074
NACRES:
NA.32
EC Number:
217-780-5
MDL number:
MFCD00067672

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Nome del prodotto

Galanthamine hydrobromide from Lycoris sp., ≥94% (HPLC)

biological source

plant (Ungeria victoris)

Quality Level

100

assay

≥94% (HPLC)

form

powder

mp

270 °C

solubility

DMSO: soluble 10 mg/mL, clear, colorless, water: soluble 20 mg/mL, clear, colorless

storage temp.

−20°C

SMILES string

Br[H].COc1ccc2CN(C)CC[C@@]34C=C[C@H](O)C[C@@H]3Oc1c24

InChI

1S/C17H21NO3.BrH/c1-18-8-7-17-6-5-12(19)9-14(17)21-16-13(20-2)4-3-11(10-18)15(16)17;/h3-6,12,14,19H,7-10H2,1-2H3;1H/t12-,14-,17-;/m0./s1

InChI key

QORVDGQLPPAFRS-XPSHAMGMSA-N

Gene Information

human ... ACHE(43)

Categorie correlate

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Questo articolo
1287755Y0001279PHL89666
Galanthamine hydrobromide from Lycoris sp. ≥94% (HPLC)

Sigma-Aldrich

G1660

Galanthamine hydrobromide from Lycoris sp.

Galantamine hydrobromide United States Pharmacopeia (USP) Reference Standard

USP

1287755

Galantamine hydrobromide

Galantamine hydrobromide European Pharmacopoeia (EP) Reference Standard

Y0001279

Galantamine hydrobromide

Galantamine hydrobromide phyproof® Reference Substance

PHL89666

Galantamine hydrobromide

biological source

plant (Ungeria victoris)

biological source

-

biological source

-

biological source

-

assay

≥94% (HPLC)

assay

-

assay

-

assay

≥95.0% (HPLC)

Gene Information

human ... ACHE(43)

Gene Information

-

Gene Information

-

Gene Information

-

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

-

form

powder

form

-

form

-

form

solid

storage temp.

−20°C

storage temp.

-

storage temp.

2-8°C

storage temp.

-

General description

Galanthamine hydrobromide is a derivative of galanthamine, which is an anticholinestrase alkaloid derived from genus Lycoris (Amaryllidaceae) or snowdrop. This compound is used for the treatment of Alzheimer′s disease (AD).[1]

Application

Galanthamine hydrobromide from Lycoris sp. has been used-
  • as an AChE (acetylcholinesterase) inhibitor and positive control in acetylcholinesterase assay performed to determine the activity of AChE[2]
  • as a positive control in the screening of AChE inhibitors[3]
  • as a positive control in AChE inhibitory assay performed to determine the AChE-inhibitory activities of pyrithione and related sulfur-containing pyridine N-oxides[4]

Biochem/physiol Actions

Cholinesterase inhibitor; reverses scopolamine-induced amnesia; antimyasthenic.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

pictograms

Skull and crossbones
GHS06

signalword

Danger

hcodes

H301

Hazard Classifications

Acute Tox. 3 Oral

Classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
BCCM5886
BCCH6300
BCCF0790
BCCC1829
BCBX4613

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Bin Hao et al.
Molecules (Basel, Switzerland), 18(3), 2458-2468 (2013-02-27)
Phytochemical investigation of the 80% ethanol extract of the bulbs of Lycoris radiata resulted in the isolation of five new Amaryllidaceae alkaloids: (+)-5,6-dehydrolycorine (1), (+)-3α,6β-diacetyl-bulbispermine (2), (+)-3α-hydroxy-6β-acetyl- bulbispermine (3), (+)-8,9-methylenedioxylhomolycorine-N-oxide (5), and 5,6-dihydro-5- methyl-2-hydroxyphenanthridine (7), together with two known compounds
Muhammad Ayaz et al.
BMC complementary and alternative medicine, 14, 145-145 (2014-06-03)
We investigated Polygonum hydropiper L. (P. hydropiper) for phenolic contents, antioxidant, anticholinesterase activities, in an attempt to rationalize its use in neurological disorders. Plant crude extract (Ph.Cr), its subsequent fractions: n-hexane (Ph.Hex), chloroform (Ph.Chf), ethyl acetate (Ph.EtAc), n-Butanol (Ph.Bt), aqueous
Petra Krejčová et al.
Journal of ethnopharmacology, 154(1), 176-182 (2014-04-12)
Persian shallot (Allium stipitatum) is a bulbous plant native to Turkey, Iran and Central Asia. It is frequently used in folk medicine for the treatment of a variety of disorders, including inflammation and stress. Antiinflammatory and neurological activities of pyrithione
Carina Wattmo et al.
BMC neurology, 12, 134-134 (2012-11-07)
Activities of daily living (ADL) are an essential part of the diagnostic criteria for Alzheimer's disease (AD). A decline in ADL affects independent living and has a strong negative impact on caregiver burden. Functional response to cholinesterase inhibitor (ChEI) treatment
Lars Sonde et al.
PloS one, 8(2), e57161-e57161 (2013-02-26)
It is largely unknown how the medical treatment of patients diagnosed with dementia is followed up in primary care. Therefore, we studied patient medical records from two dementia clinics and from the referring primary care centres. A retrospective study of
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Contenuto correlato

Product Information Sheet - G1660

Product Information Sheet

Numero articolo commerciale globale

SKUGTIN
G1660-10MG04061833628324
G1660-2MG04061833628331

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