Skip to Content
Merck

Key Documents

View All Documentation

Skip To

G013

R(+)-Baclofen hydrochloride

solid

Synonym(s):

Arbaclofen hydrochloride, R(+)-β-(Aminomethyl)-4-chlorobenzenepropanoic acid hydrochloride, STX209

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View
Pack SizeSKUAvailabilityPrice
25 mg
Please contact Customer Service for Availability
CZK 5,340.00
100 mg
Please contact Customer Service for Availability
CZK 17,000.00
500 mg
Please contact Customer Service for Availability
CZK 62,200.00

About This Item

Empirical Formula (Hill Notation):
C10H12ClNO2 · HCl
CAS Number:
63701-55-3
Molecular Weight:
250.12
NACRES:
NA.32
PubChem Substance ID:
24895006
UNSPSC Code:
12352200
MDL number:
MFCD00078579

CZK 5,340.00

Please contact Customer Service for Availability
​
Request a Bulk Order
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

form

solid

Quality Level

100

optical activity

[α]28/D +3.8°, c = 0.9 in methanol(lit.)

storage condition

desiccated

color

white

solubility

DMSO: >20 mg/mL, H2O: 26 mg/mL (Solutions may be stored for several weeks at 4 °C.)

SMILES string

Cl[H].NC[C@H](CC(O)=O)c1ccc(Cl)cc1

InChI

1S/C10H12ClNO2.ClH/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14;/h1-4,8H,5-6,12H2,(H,13,14);1H/t8-;/m0./s1

InChI key

WMNUVYYLMCMHLU-QRPNPIFTSA-N

Gene Information

human ... GABBR1(2550)
mouse ... GABBR1(54393)
rat ... GABBR1(81657)

Compare Similar Items

View Full Comparison

Show Differences

1 of 1

This Item
P118B5399D4000
R(+)-Baclofen hydrochloride solid

Sigma-Aldrich

G013

R(+)-Baclofen hydrochloride

Phaclofen solid

Sigma-Aldrich

P118

Phaclofen

(±)-Baclofen ≥98% (HPLC), solid

Sigma-Aldrich

B5399

(±)-Baclofen

trans-Dehydroandrosterone ≥99%

Sigma-Aldrich

D4000

trans-Dehydroandrosterone

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

200

form

solid

form

solid

form

solid

form

crystalline powder

Gene Information

human ... GABBR1(2550)
mouse ... GABBR1(54393)
rat ... GABBR1(81657)

Gene Information

human ... GABBR1(2550), GABBR2(9568)

Gene Information

human ... GABBR1(2550), GABBR2(9568)
rat ... Gabbr1(81657), Gabra2(29706)

Gene Information

human ... GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SERPINA6(866)
rat ... Ar(24208)

storage condition

desiccated

storage condition

-

storage condition

-

storage condition

-

optical activity

[α]28/D +3.8°, c = 0.9 in methanol(lit.)

optical activity

-

optical activity

-

optical activity

-

color

white

color

white

color

white to very faintly yellow

color

-

Application

R(+)-Baclofen hydrochloride has been used as a GABAB receptor agonist to study its effects on M43068-induced antinociception in rat models.[1] It has also been used as a GABAB receptor agonist to study its effects on amphetamine-induced behavior and neurochemical responses in rat striatum.

Biochem/physiol Actions

Baclofen is a derivative of γ-aminobutyric acid (GABA) and acts as a 4-aminobutanoic acid receptor (GABAB) agonist. It interacts stereospecifically with the GABA receptor and exhibits antispastic effects.Baclofen shows therapeutic effects against paroxysmal pain of trigeminal neuralgia and spinal spasticity. R(+)-Baclofen is a more active enantiomer.

Other Notes

Same enantiomer as R(−)-baclofen free base.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number
0000444300
0000444300
0000122690
0000122691
0000086592

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Yuriko Watanabe et al.
European journal of pharmacology, 837, 88-95 (2018-08-08)
The nucleus accumbens contains delta-opioid receptors that may decrease inhibitory neurotransmission. As GABAB receptors inhibit dopamine release, decrease in activation of GABAB receptors may be a mediator of delta-opioid receptor-induced accumbal dopamine efflux. If so, accumbal dopamine efflux induced by
Synthesis of both enantiomers of baclofen using (R)-and (S)-N-phenylpantolactam as chiral auxiliaries
Camps P, et al.
Tetrahedron Asymmetry, 15(13) (2004)
Ya-Qun Zhou et al.
The journal of pain, 18(8), 933-946 (2017-03-23)
Cancer-induced bone pain (CIBP) remains a major challenge in advanced cancer patients because of our lack of understanding of its mechanisms. Previous studies have shown the vital role of γ-aminobutyric acid B receptors (GABABRs) in regulating nociception and various neuropathic
Xia Li et al.
Neuropharmacology, 97, 357-364 (2015-05-24)
GABAB (γ-aminobutyric acid B) receptors may be a therapeutic target for anxiety disorders. Here we characterized the effects of the GABAB receptor positive allosteric modulator (PAM) BHF177 on conditioned and unconditioned physiological responses to threat in the light-enhanced startle (LES)
Yasushige Akada et al.
European journal of pharmacology, 523(1-3), 46-53 (2005-10-18)
We investigated the effects of 2-(4-hydroxybenzoyl)amino-2-methylpropionic acid (M43068), a novel analgesic agent, in rat models of acute and neuropathic pain. Oral M43068 (10-100 mg/kg) suppressed only the late phase of formalin-induced nociceptive behaviors. In the neuropathic pain model, oral M43068
View All Related Papers

Protocols

Qualitative Thin Layer Chromatography Analysis Ginkgo

Qualitative Thin Layer Chromatography Analysis of Flavonoids and Quantification of Terpene Lactones in Ginkgo Biloba Extracts and Tablets

Global Trade Item Number

SKUGTIN
G013-100MG04061833623213
G013-25MG04061833623220

Questions

Reviews

No rating value

Active Filters

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service