A5229
Agitoxin-1
recombinant, expressed in E. coli, ≥98% (HPLC), lyophilized powder
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About This Item
MDL number:
UNSPSC Code:
12352200
assay
≥98% (HPLC)
form
lyophilized powder
mol wt
4021 Da
solubility
H2O: soluble
aqueous buffer: soluble
storage temp.
−20°C
Amino Acid Sequence
Gly-Val-Pro-Ile-Asn-Val-Lys-Cys-Thr-Gly-Ser-Pro-Gln-Cys-Leu-Lys-Pro-Cys-Lys-Asp-Ala-Gly-Met-Arg-Phe-Gly-Lys-Cys-Ile-Asn-Gly-Lys-Cys-His-Cys-Thr-Pro-Lys
Application
Agitoxin-1 is a potent blocker of the Shakervoltage-gated K+ channels. Agitoxin has also been used to improve multi-dimensional NMR of proteins.
Biochem/physiol Actions
Toxin found in the venom of the scorpion Leiurus quinquestriatus hebraeus. Potent blocker of the Shaker voltage-gated K+ channels as well as the mammalian homologues of Shaker
Storage Class
13 - Non Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, type N95 (US)
Certificates of Analysis (COA)
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Eriks Kupce et al.
Journal of biomolecular NMR, 25(4), 349-354 (2003-05-27)
Three-dimensional HNCO and HNCA subspectra from a small protein (agitoxin, 4 kDa, enriched in carbon-13 and nitrogen-15), have been obtained by direct frequency-domain excitation of selected carbon and nitrogen sites. This new technique applies an array of several simultaneous soft
G Suarez-Kurtz et al.
The Journal of pharmacology and experimental therapeutics, 289(3), 1517-1522 (1999-05-21)
Potent and selective peptidyl blockers of the Shaker-type (Kv1) voltage-gated potassium channels were used to determine the role of these channels in regulating the spontaneous motility of smooth muscle preparations. Margatoxin (MgTX), kaliotoxin, and agitoxin-2 at 1 to 10 nM
M L Garcia et al.
Biochemistry, 33(22), 6834-6839 (1994-06-07)
Three new toxins from the venom of the scorpion Leiurus quinquestriatus var. hebraeus have been identified on the basis of their ability to block the Shaker K+ channel. These toxins have been purified using HPLC techniques and characterized as 38
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