M8010

N,N′-Dimethyl-9,9′-biacridinium dinitrate

Name: <I>N,N</I>&#8242;-Dimethyl-9,9&#8242;-biacridinium dinitrate
Brand: SIAL

Powder

Synonym(s):

9,9′-Bis(N-methylacridinium nitrate), Lucigenin

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About This Item

Empirical Formula (Hill Notation):

C₂₈H₂₂N₄O₆

CAS Number:

2315-97-1

Molecular Weight:

510.50

NACRES:

NA.47

PubChem Substance ID:

24897210

UNSPSC Code:

12171500

EC Number:

219-023-4

MDL number:

MFCD00011925

Beilstein/REAXYS Number:

3901768

Key Documents

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Product Name

N,N′-Dimethyl-9,9′-biacridinium dinitrate, used as chemiluminescent reagent

Quality Level

100

form

powder

mp

245-250 °C

solubility

acetic acid: 10 mg/mL

fluorescence

λ_ex 319 nm; λ_em 384 nm (pH 9.0), λ_ex 360 nm; λ_em 449 nm (Reaction product), λ_ex 368 nm; λ_em 505 nm in H₂O

application(s)

diagnostic assay manufacturing
hematology
histology

storage temp.

room temp

SMILES string

[O-][N+]([O-])=O.[O-][N+]([O-])=O.C[n+]1c2ccccc2c(-c3c4ccccc4[n+](C)c5ccccc35)c6ccccc16

InChI

1S/C28H22N2.2NO3/c1-29-23-15-7-3-11-19(23)27(20-12-4-8-16-24(20)29)28-21-13-5-9-17-25(21)30(2)26-18-10-6-14-22(26)28;2*2-1(3)4/h3-18H,1-2H3;;/q+2;2*-1

InChI key

KNJDBYZZKAZQNG-UHFFFAOYSA-N

Related Categories

Clinical & Diagnostics

Hematology Stains

Histology Stains

Tissue Diagnostics

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Show Differences

1 of 4

This Item	C1154	201715	219215
Sigma-Aldrich M8010 N,N′-Dimethyl-9,9′-biacridinium dinitrate	C1154 4-Chloro-7-sulfobenzofurazan ammonium salt	Sigma-Aldrich 201715 Pinacyanol chloride	219215 Leucocrystal Violet
fluorescence λ_ex 319 nm; λ_em 384 nm (pH 9.0), λ_ex 368 nm; λ_em 505 nm in H₂O, λ_ex 360 nm; λ_em 449 nm (Reaction product)	fluorescence λ_ex 360 nm; λ_em 410 nm (pH 8.5), λ_ex 383 nm; λ_em 528 nm (Reaction product)	fluorescence -	fluorescence -
solubility acetic acid: 10 mg/mL	solubility water: 50 mg/mL, clear, dark yellow	solubility -	solubility -
form powder	form powder	form powder	form powder
application(s) diagnostic assay manufacturing hematology histology	application(s) diagnostic assay manufacturing hematology histology	application(s) diagnostic assay manufacturing hematology histology	application(s) diagnostic assay manufacturing hematology histology
Quality Level 100	Quality Level 200	Quality Level 100	Quality Level 200
storage temp. room temp	storage temp. room temp	storage temp. room temp	storage temp. room temp

Application

N,N′-Dimethyl-9,9′-biacridinium dinitrate has been used in chemiluminescence assay to measure reactive oxygen species production and superoxide production.[1]

Reagent used for the generation of chemiluminescence in the presence of a reductant and oxygen; it is employed in numerous chemiluminescent assays. Lucigenin is specific for superoxide anion radical.

Storage Class

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type N95 (US)

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Toll-like receptor-4 is involved in eliciting an LPS-induced oxidative burst in neutrophils

Remer KA, et al.

Immunology Letters, 85, 75-80 (2003)

Combination of cilostazol and probucol protected podocytes from lipopolysaccharide-induced injury by both anti-inflammatory and anti-oxidative mechanisms

He P, et al.

Journal of Nephrology, 30, 531-541 (2017)

Enhanced XOR activity in eNOS-deficient mice: effects on the nitrate-nitrite-NO pathway and ROS homeostasis

Peleli M, et al.

Free Radical Biology & Medicine, 99, 472-484 (2016)

Neutrophil superoxide release and plasma C-reactive protein levels pre- and post-periodontal therapy.

Ling MR

Journal of Clinical Periodontology, 43, 652-652 (2016)

LPS-induced renal inflammation is prevented by (-)-epicatechin in rats.

Paula Denise Prince et al.

Redox biology, 11, 342-349 (2017-01-01)

This work investigated the capacity of (-)-epicatechin to prevent the renal damage induced by LPS administration in rats. Male Sprague Dawley rats were fed for 4 days a diet without or with supplementation with (-)-epicatechin (80mg/kg BW/d), and subsequently i.p.

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Global Trade Item Number

SKU	GTIN
M8010-1G	04061834062578
M8010-5G	04061832343600
M8010-500MG	04061834062585

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