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Parteck® MXP (Polyvinyl alcohol 3-82)

EMPROVE® ESSENTIAL, Ph. Eur.

Pharma Manufacturing

Synonym(s):

Parteck® Polyvinyl alcohol, PVA, Polyvinyl alcohol

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About This Item

Linear Formula:
(C2H4O)n
CAS Number:
9002-89-5
MDL number:
MFCD00081922
UNSPSC Code:
12352104

Agency

Ph. Eur.

Quality Level

500

product line

EMPROVE® ESSENTIAL

form

powder

application(s)

pharmaceutical
solid formulation
solubility enhancement

storage temp.

15-25°C

InChI

1S/C2H4O/c1-2-3/h2-3H,1H2

InChI key

IMROMDMJAWUWLK-UHFFFAOYSA-N

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General description

With a lower degree of hydrolysis along the PVA chain, Parteck® MXP 3-82 Polyvinyl alcohol is especially beneficial in forming strong interac­tions with hydrophobic drug molecules – in the solid state and in solution. Due to this, Parteck® MXP 3-82 excipient has very high capabilities as a precipitation inhibitor and can maintain high levels of supersaturation for physiologi­cally relevant timescales. As a result, Parteck® MXP 3-82 Polyvinyl alcohol can provide solubility enhancement for even the most challenging molecules.

Application

Parteck® MXP 3-82 is a PVA-based excipient that is used in Hot Melt Extrusion for Solubility Enhancement in oral solid dosage forms.

Features and Benefits

  • Superior supersaturation performance via precipitation inhibition
  • High thermostability up to 250°C, extending the potential application range
  • Stable high drug loads and suitability with a broad range of APIs
  • Flexible release kinetics
  • Compatible with several downstream processing capabilities, like direct compression, continuous manufacturing, thin film extrusion and 3D printing
  • Optimized powder properties for excellent performance in the HME process
  • Suitable polymer properties for HME, spray drying and 3D printing processes

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany
PARTECK is a registered trademark of Merck KGaA, Darmstadt, Germany

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Storage Class Code

11 - Combustible Solids

WGK

WGK 1

Flash Point(F)

No data available

Flash Point(C)

No data available

Certificates of Analysis (COA)

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Articles

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3D printing can overcome challenges during formulation development, with a focus on enhancing API bioavailability in solid dispersions. Find out how in this technical article.

API Solubility and Dissolution Enhancement Via Formulation

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