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Sigma-Aldrich

Cyclopropanesulfonyl chloride

95%

Synonym(s):

Cyclopropylsulfonyl chloride

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About This Item

Empirical Formula (Hill Notation):
C3H5ClO2S
CAS Number:
139631-62-2
Molecular Weight:
140.59
MDL number:
MFCD01631933
UNSPSC Code:
12352100
PubChem Substance ID:
24882651
NACRES:
NA.22

Quality Level

100

assay

95%

refractive index

n20/D 1.4770 (lit.)

density

1.38 g/mL at 25 °C (lit.)

storage temp.

2-8°C

SMILES string

ClS(=O)(=O)C1CC1

InChI

1S/C3H5ClO2S/c4-7(5,6)3-1-2-3/h3H,1-2H2

InChI key

PFWWSGFPICCWGU-UHFFFAOYSA-N

Application

Cyclopropanesulfonyl chloride can be used in the synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic sulfonamide derivatives, which can serve as building blocks in the preparation of potent hepatitis C virus NS3 protease inhibitors.

pictograms

Corrosion
GHS05

signalword

Danger

hcodes

H314

Hazard Classifications

Skin Corr. 1B

Storage Class

8A - Combustible corrosive hazardous materials

wgk_germany

WGK 3

flash_point_f

204.8 °F - closed cup

flash_point_c

96 °C - closed cup

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

Certificates of Analysis (COA)

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"Concise asymmetric synthesis of a (1R, 2S)-1-amino-2-vinylcyclopropanecarboxylic acid-derived sulfonamide and ethyl ester"
Lou Sha, et al.
Organic & Biomolecular Chemistry, 11(39), 6796-6805 (2013)

Articles

Sulfonyl Chlorides and Sulfonamides

Sulfonyl chlorides are often chosen as building blocks in medicinal chemistry for their ability to easily react with heterocyclic amines to create complex sulfonamides.

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