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39391

Sigma-Aldrich

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide

≥97.0% (T), for peptide synthesis

Synonym(s):

N-Ethyl-N′-(3-dimethylaminopropyl)carbodiimide, EDC, WSC

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About This Item

Empirical Formula (Hill Notation):
C8H17N3
CAS Number:
1892-57-5
Molecular Weight:
155.24
Beilstein/REAXYS Number:
507429
EC Number:
217-579-2
MDL number:
MFCD00044916
UNSPSC Code:
12352116
PubChem Substance ID:
57649895
NACRES:
NA.22

product name

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide, ≥97.0% (T)

Quality Level

100

assay

≥97.0% (T)

form

liquid

reaction suitability

reaction type: Coupling Reactions

refractive index

n20/D 1.461

density

0.877 g/mL at 20 °C (lit.)

application(s)

peptide synthesis

functional group

amine

storage temp.

−20°C

SMILES string

CCN=C=NCCCN(C)C

InChI

1S/C8H17N3/c1-4-9-8-10-6-5-7-11(2)3/h4-7H2,1-3H3

InChI key

LMDZBCPBFSXMTL-UHFFFAOYSA-N

General description

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide is commonly used in combination with N-hydroxysuccinimide (NHS) in carbodiimide coupling reaction to activate carboxyl group for coupling with amines to form amides.

Application

N-(3-Dimethylaminopropyl)-N′-ethylcarbodiimide has been used for the surface functionalization of graphene quantum dots (GQDs) employed as sensing probes in Janus micromotors to detect enterobacterial contamination. It has also been used for the activation of folic acid, prior to its conjugation on silica nanoparticles.

signalword

Danger

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Skin Corr. 1A - Skin Sens. 1A - STOT RE 2 Oral

target_organs

Stomach,large intestine,lymph node

Storage Class

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Faceshields, Gloves, Goggles, type ABEK (EN14387) respirator filter

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Certificates of Analysis (COA)

Lot/Batch Number
BCCM2788
BCCK2801
BCCL1199
BCCH5279
BCCG0572

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J David Stack et al.
Journal of tissue engineering and regenerative medicine, 11(10), 2785-2795 (2016-05-21)
Osteochondral lesions resulting from osteochondritis dissecans are problematic to treat and present a significant challenge for clinicians. The aims of this study were to investigate the use of a scaffold-assisted microfracture approach, employing a novel, multilayered, collagen-based, osteochondral graft substitute
Anthony C Y Yau et al.
Scientific reports, 7(1), 14998-14998 (2017-11-10)
Mineral oils are extensively used in our daily life, in food, cosmetics, biomedicine, vaccines and in different industrial applications. However, exposure to these mineral oils has been associated with immune adjuvant effects and the development of autoimmune diseases. Here we
Ruogu Qi et al.
Nature communications, 8(1), 2166-2166 (2017-12-20)
Advanced-stage epithelial ovarian cancers are amongst the most difficult to treat tumors and have proven to be refractory to most cytotoxic, molecularly targeted, or immunotherapeutic approaches. Here, we report that nanoparticle-drug conjugates (NDCs) of monomethyl auristatin E (MMAE) significantly increase
Yumei Wang et al.
Materials science & engineering. C, Materials for biological applications, 103, 109737-109737 (2019-07-28)
In this study, twisted rod-like chiral mesoporous silicas (CMSs) with discriminating chiral characteristics (D/L) were designed and biomimetic synthesized by using L- and d-alanine derivatives as templates, and employed as poorly water-soluble chiral drug ibuprofen (IBU) carriers. The morphology and
Folic acid-conjugated organically modified silica nanoparticles for enhanced targeted delivery in cancer cells and tumor in vivo.
Yin F
Journal of Material Chemistry B: Materials for Biology and Medicine, 3(29), 6081-6093 (2015)
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